Associations Among Tremor Amplitude, Activities of Daily Living, and Quality of Life in Patients with Essential Tremor.

Background

Essential tremor (ET) is a disabling syndrome consisting of tremor, primarily in the upper limbs. We assessed the correlation of The Essential Tremor Rating Assessment Scale (TETRAS) Performance Item 4 ratings of upper limb tremor with the TETRAS activities of daily living (ADL) subscale and with 2 quality of life (QoL) scales.

Methods

This noninterventional, cross-sectional, point-in-time survey of neurologists(n = 60), primary care physicians (n = 38), and their patients with ET (n = 1,003) used real-world data collected through the Adelphi ET Disease Specific Programme™. Physician-reported measures (TETRAS Performance Item 4 and TETRAS ADL total) and patient-reported QoL measures (generic EuroQol-5 Dimension 5 Level [EQ-5D-5 L] and ET-specific Quality of Life in Essential Tremor Questionnaire (QUEST)) were assessed with bivariate and multivariable analyses. Sensitivity analyses were also conducted.

Results

The bivariate association between TETRAS Performance Item 4 score and TETRAS ADL total score was high (Pearson r = 0.761,

Discussion

This study showed that greater tremor severity (TETRAS Performance Item 4) was positively correlated with ADL impairment (TETRAS ADL) and negatively associated with QoL (EQ-5D-5 L and QUEST). TETRAS Performance Item 4 score is a robust predictor of TETRAS ADL total score, and TETRAS Performance Item 4 and TETRAS ADL total scores were robust predictors of the 2 QoL scales. The results demonstrate the value of TETRAS scores as valid endpoints for future clinical trials.

Highlights

This real-world study assessed TETRAS scores as predictors of impaired QoL in ET. TETRAS Performance Item 4 and ADL were associated with EQ-5D-5 L and QUEST. TETRAS scores may serve as valid endpoints for future clinical trials.

Informations de copyright

Copyright: © 2024 The Author(s).

Déclaration de conflit d'intérêts

Margaret E Gerbasi reports financial support was provided by SAGE Therapeutics Inc. Margaret E Gerbasi reports financial support was provided by Biogen. Margaret E Gerbasi reports a relationship with SAGE Therapeutics Inc that includes: employment and equity or stocks. Rodger J Elble reports a relationship with Applied Therapeutics Inc that includes: consulting or advisory. Rodger J Elble reports a relationship with Attune that includes: consulting or advisory. Rodger J Elble reports a relationship with Cadent Medical Communications that includes: consulting or advisory. Rodger J Elble reports a relationship with Cavion that includes: consulting or advisory. Rodger J Elble reports a relationship with Cydan that includes: consulting or advisory. Rodger J Elble reports a relationship with Five Microns that includes: consulting or advisory. Rodger J Elble reports a relationship with Jazz Pharmaceuticals Inc that includes: consulting or advisory. Rodger J Elble reports a relationship with Osmotica Pharmaceuticals LLC that includes: consulting or advisory. Rodger J Elble reports a relationship with Praxis Precision Medicines Inc that includes: consulting or advisory. Rodger J Elble reports a relationship with SAGE Therapeutics Inc that includes: consulting or advisory. Eddie Jones reports a relationship with Adelphi Real World that includes: employment. Alexander Gillespie reports a relationship with Adelphi Real World that includes: employment. John Jarvis reports a relationship with Medicus Economics that includes: employment. John Jarvis reports a relationship with SAGE Therapeutics Inc that includes: consulting or advisory. John Jarvis reports a relationship with Biogen that includes: consulting or advisory. Elizabeth Chertavian reports a relationship with Medicus Economics that includes: employment. Elizabeth Chertavian reports a relationship with SAGE Therapeutics Inc that includes: consulting or advisory. Elizabeth Chertavian reports a relationship with Biogen that includes: consulting or advisory. Zachary Smith reports a relationship with Medicus Economics that includes: employment. Zachary Smith reports a relationship with SAGE Therapeutics Inc that includes: consulting or advisory. Zachary Smith reports a relationship with Biogen that includes: consulting or advisory. Mina Nejati reports a relationship with Biogen that includes: employment and equity or stocks. Ludy C Shih reports a relationship with WCG MedAvante that includes: consulting or advisory. Ludy C Shih reports a relationship with Encora Therapeutics that includes: consulting or advisory.