Improvement of anti-prion efficacy with stearoxy conjugation of hydroxypropyl methylcellulose in prion-infected mice.

Animals Hypromellose Derivatives / chemistry Mice Prion Diseases / drug therapy Disease Models, Animal
Film Hydroxypropyl methylcellulose Prion disease Prophylaxis Stearoxy ester

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
01 Aug 2024
Historique:
received: 27 12 2023
revised: 11 04 2024
accepted: 12 04 2024
medline: 7 5 2024
pubmed: 7 5 2024
entrez: 6 5 2024
Statut: ppublish

Résumé

Prion diseases are fatal transmissible neurodegenerative disorders. Among known anti-prions, hydroxypropyl methylcellulose compounds (HPMCs) are unique in their chemical structure and action. They have several excellent anti-prion properties but the effectiveness depends on the prion-infected mouse model. In the present study, we investigated the effects of stearoxy-modified HPMCs on prion-infected cells and mice. Stearoxy modification improved the anti-prion efficacy of HPMCs in prion-infected cells and significantly prolonged the incubation period in a lower HPMC-responding mouse model. However, stearoxy modification showed no improvement over nonmodified HPMCs in an HPMC-responding mouse model. These results offer a new line of inquiry for use with prion-infected mice that do not respond well to HPMCs.

Identifiants

DOI: 10.1016/j.carbpol.2024.122163 PMID: 38710557
pubmed: 38710557
pii: S0144-8617(24)00389-8
doi: 10.1016/j.carbpol.2024.122163
pii:
doi:

Substances chimiques

Hypromellose Derivatives 3NXW29V3WO

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

122163

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kenta Teruya reports financial support was provided by the Japan Society for the Promotion of Science [grant numbers 19K22479 and 23K05036]. Kenta Teruya has patent #P2017-93414 issued to Tohoku University. Katsumi Doh-ura has patent #P2017-93414 issued to Tohoku University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Kenta Teruya (K)

Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Electronic address: kenta.teruya.d4@tohoku.ac.jp.

Ayumi Oguma (A)

Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Electronic address: ogm3@med.tohoku.ac.jp.

Sara Iwabuchi (S)

Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Electronic address: neurochemistry@med.tohoku.ac.jp.

Keiko Nishizawa (K)

Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Electronic address: nishizawa@med.tohoku.ac.jp.

Katsumi Doh-Ura (K)

Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Faculty of Medical Science & Welfare, Tohoku Bunka Gakuen University, Sendai, Miyagi, Japan. Electronic address: doh-ura@med.tohoku.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Improvement of anti-prion efficacy with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biopolymères › Cellulose › Dérivés de l'hypromellose › Improvement of anti-prion efficacy with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Improvement of anti-prion efficacy with...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladies à prions › Improvement of anti-prion efficacy with...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Improvement of anti-prion efficacy with...