Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets.
Zinc Oxide
/ chemistry
Humans
Anti-Bacterial Agents
/ pharmacology
Catalysis
Antineoplastic Agents
/ pharmacology
Nanostructures
/ chemistry
Escherichia coli
/ drug effects
Ciprofloxacin
/ pharmacology
Staphylococcus aureus
/ drug effects
Microbial Sensitivity Tests
Cell Line, Tumor
Photochemical Processes
Photolysis
Antibiotic degradation
Anticancer
Antimicrobial activity
Photocatalysis
Sunlight
ZnO nanosheet
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 May 2024
06 May 2024
Historique:
received:
16
02
2024
accepted:
16
04
2024
medline:
7
5
2024
pubmed:
7
5
2024
entrez:
6
5
2024
Statut:
epublish
Résumé
Active pharmaceutical ingredients have emerged as an environmentally undesirable element because of their widespread exploitation and consequent pollution, which has deleterious effects on living things. In the pursuit of sustainable environmental remediation, biomedical applications, and energy production, there has been a significant focus on two-dimensional materials (2D materials) owing to their unique electrical, optical, and structural properties. Herein, we have synthesized 2D zinc oxide nanosheets (ZnO NSs) using a facile and practicable hydrothermal method and characterized them thoroughly using spectroscopic and microscopic techniques. The 2D nanosheets are used as an efficient photocatalyst for antibiotic (herein, end-user ciprofloxacin (CIP) was used as a model antibiotic) degradation under sunlight. It is observed that ZnO NSs photodegrade ~ 90% of CIP within two hours of sunlight illumination. The molecular mechanism of CIP degradation is proposed based on ex-situ IR analysis. Moreover, the 2D ZNO NSs are used as an antimicrobial agent and exhibit antibacterial qualities against a range of bacterial species, including Escherichia coli, Staphylococcus aureus, and MIC of the bacteria are found to be 5 μg/l and 10 μg/l, respectively. Despite having the biocompatible nature of ZnO, as-synthesized nanosheets have also shown cytotoxicity against two types of cancer cells, i.e. A549 and A375. Thus, ZnO nanosheets showed a nontoxic nature, which can be exploited as promising alternatives in different biomedical applications.
Identifiants
pubmed: 38710736
doi: 10.1038/s41598-024-59842-6
pii: 10.1038/s41598-024-59842-6
doi:
Substances chimiques
Zinc Oxide
SOI2LOH54Z
Anti-Bacterial Agents
0
Antineoplastic Agents
0
Ciprofloxacin
5E8K9I0O4U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10406Subventions
Organisme : Science and Engineering Research Board
ID : SRG/2022/001389
Informations de copyright
© 2024. The Author(s).
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