Intraoperative quantitative crystalline lens nuclear opacities analysis based on crystalline lenSx platform.
Clinical prediction model
Femtosecond laser assisted cataract surgery
Lens nucleus density
Spectral domain optical coherence tomography imaging
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
06 May 2024
06 May 2024
Historique:
received:
06
02
2024
accepted:
03
04
2024
medline:
7
5
2024
pubmed:
7
5
2024
entrez:
6
5
2024
Statut:
epublish
Résumé
The main objective is to quantify the lens nuclear opacity using spectral-domain optical coherence tomography (SD-OCT) and to evaluate its association with Lens Opacities Classification System III (LOCS-III) system, lens thickness (LT), and surgical parameters. The secondary objective is to assess the diagnostic model performance for hard nuclear cataract. This study included 70 eyes of 57 adults with cataract, with 49 (70%) and 21 (30%) in training and validation cohort, respectively. Correlations of the average nuclear density (AND) /maximum nuclear density (MND) with LOCS-III scores, LT, and surgical parameters were analyzed. Univariate and multivariate logistic regression analysis, receiver operating characteristic curves and calibration curves were performed for the diagnostic of hard nuclear cataract. The pre-operative uncorrected distance visual acuity (UDVA), intraocular pressure (IOP), mean axial length (AL), and LT were 1.20 ± 0.47 log MAR, 15.50 ± 2.87 mmHg, 27.34 ± 3.77 mm and 4.32 ± 0.45 mm, respectively. The average nuclear opalescence (NO) and nuclear colour (NC) scores were 3.61 ± 0.94 and 3.50 ± 0.91 (ranging from 1.00 to 6.90), respectively. The average AND and MND were 137.94 ± 17.01 and 230.01 ± 8.91, respectively. NC and NO scores both significantly correlated with the AND (rNC = 0.733, p = 0.000; rNO = 0.755, p = 0.000) and MND (rNC = 0.643, p = 0.000; rNO = 0.634, p = 0.000). In the training cohort, the area under the curve (AUC) of the model was 0.769 (P < 0.001, 95%CI 0.620-0.919), which had a good degree of differentiation (Fig. 2a). The calibration curve showed good agreement between predicted and actual probability. The nuclear density measurement on SD-OCT images can serve as an objective and reliable indicator for quantifying nuclear density.
Identifiants
pubmed: 38711059
doi: 10.1186/s12886-024-03431-8
pii: 10.1186/s12886-024-03431-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206Informations de copyright
© 2024. The Author(s).
Références
WHO. Blindness and vision impairment. https://www.who.int/en/news-room/fact-sheets/detail/blindness-and-visual-impairment . Accessed 24 Jan 2023.2.
Camacho-Barcia ML, Bulló M, Garcia-Gavilán JF, Ruiz-Canela M, Corella D, Estruch R, Fitó M, García-Layana A, Arós F, Fiol M, Lapetra J, Serra-Majem L, Pintó X, García-Arellano A, Vinyoles E, Sorli JV, Salas-Salvadó J. Association of dietary vitamin K1 intake with the incidence of cataract surgery in an adult mediterranean population: a secondary analysis of a randomized clinical trial. JAMA Ophthalmol. 2017;135(6):657–61.
doi: 10.1001/jamaophthalmol.2017.1076
pubmed: 28494067
pmcid: 5847084
Lee CM, Afshari NA. The global state of cataract blindness. Curr Opin Ophthalmol. 2017;28(1):98–103.
doi: 10.1097/ICU.0000000000000340
pubmed: 27820750
Day AC, Burr JM, Bennett K, Bunce C, Doré CJ, Rubin GS, Nanavaty MA, Balaggan KS, Wilkins MR, FACT group. Femtosecond laser-assisted cataract surgery versus phacoemulsification cataract surgery (FACT): A randomized noninferiority trial. Ophthalmology. 2020;127(8):1012–9.
doi: 10.1016/j.ophtha.2020.02.028
pubmed: 32386810
Charalampidou S, Nolan J, Loughman J, Stack J, Higgins G, Cassidy L, Beatty S. Psychophysical impact and optical and morphological characteristics of symptomatic non-advanced cataract. Eye (Lond). 2011;25(9):1147–54.
doi: 10.1038/eye.2011.123
pubmed: 21660066
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY. The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol. 1993;111(6):831–6.
doi: 10.1001/archopht.1993.01090060119035
pubmed: 8512486
Sparrow JM, Bron AJ, Brown NA, Ayliffe W, Hill AR. The Oxford clinical cataract classification and grading system. Int Ophthalmol. 1986;9(4):207–25.
doi: 10.1007/BF00137534
pubmed: 3793374
Klein BE, Klein R, Linton KL, Magli YL, Neider MW. Assessment of cataracts from photographs in the beaver dam eye study. Ophthalmology. 1990;97(11):1428–33.
doi: 10.1016/S0161-6420(90)32391-6
pubmed: 2255515
Adamsons I, Taylor KI, Enger C, Taylor HR. A new method for documenting lens opacities. Am J Ophthalmol. 1991;111(1):65–70.
doi: 10.1016/S0002-9394(14)76899-0
pubmed: 1985493
Sasaki K, Sasaki H, Jonasson F, Kojima M, Cheng HM. Racial differences of lens transparency properties with aging and prevalence of age-related cataract applying a WHO classification system. Ophthalmic Res. 2004;36(6):332–40.
doi: 10.1159/000081636
pubmed: 15627834
Grulkowski I, Manzanera S, Cwiklinski L, Mompeán J, de Castro A, Marin JM, Artal P. Volumetric macro- and micro-scale assessment of crystalline lens opacities in cataract patients using long-depth-range swept source optical coherence tomography. Biomed Opt Express. 2018;9(8):3821–33.
doi: 10.1364/BOE.9.003821
pubmed: 30338158
pmcid: 6191641
Faria-Correia F, Lopes B, Monteiro T, Franqueira N, Ambrósio R Jr. Scheimpflug lens densitometry and ocular wavefront aberrations in patients with mild nuclear cataract. J Cataract Refract Surg. 2016;42(3):405–11.
doi: 10.1016/j.jcrs.2015.10.069
pubmed: 27063521
Haddad JS, Borges C, Daher ND, Mine A, Salomão M, Ambrósio R Jr. Correlations of immediate corneal tomography changes with preoperative and the elapsed phaco parameters. Clin Ophthalmol. 2022;4(16):2421–8.
doi: 10.2147/OPTH.S363185
Kanclerz P, Alio JL. The benefits and drawbacks of femtosecond laser-assisted cataract surgery. Eur J Ophthalmol. 2021;31(3):1021–30.
doi: 10.1177/1120672120922448
pubmed: 32508179
Roberts HW, Day AC, O’Brart DP. Femtosecond laser-assisted cataract surgery: A review. Eur J Ophthalmol. 2020;30(3):417–29.
doi: 10.1177/1120672119893291
pubmed: 31801354
Gunalan A, Mattos LS. Towards OCT-Guided endoscopic laser surgery-a review. Diagnostics (Basel). 2023;13(4):677.
doi: 10.3390/diagnostics13040677
pubmed: 36832167
Dsouza R, Won J, Monroy GL, Spillman DR, Boppart SA. Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications. J Biomed Opt. 2018;23(9):1–11.
doi: 10.1117/1.JBO.23.9.096003
pubmed: 30251484
Lavaud A, Soukup P, Martin L, Hartnack S, Pot S. Spectral domain optical coherence tomography in awake rabbits allows identification of the visual streak, a comparison with histology. Transl Vis Sci Technol. 2020;9(5):13.
doi: 10.1167/tvst.9.5.13
pubmed: 32821485
pmcid: 7401941
Chen D, Tang Q, Yu F, Cai X, Lu F. Consecutive drilling combined with phaco chop for full thickness segmentation of very hard nucleus in coaxial microincisional cataract surgery. BMC Ophthalmol. 2019;19(1):20.
doi: 10.1186/s12886-019-1033-1
pubmed: 30651088
pmcid: 6335814
Schroeder AB, Dobson ETA, Rueden CT, Tomancak P, Jug F, Eliceiri KW. The ImageJ ecosystem: Open-source software for image visualization, processing, and analysis. Protein Sci. 2021;30(1):234–49.
doi: 10.1002/pro.3993
pubmed: 33166005
Kim YN, Park JH, Tchah H. Quantitative analysis of lens nuclear density using optical coherence tomography (OCT) with a liquid optics interface: correlation between OCT Images and LOCS III Grading. J Ophthalmol. 2016;2016:3025413.
doi: 10.1155/2016/3025413
pubmed: 27651952
pmcid: 5019885
Makhotkina NY, Berendschot T, van den Biggelaar F, Weik ARH, Nuijts R. Comparability of subjective and objective measurements of nuclear density in cataract patients. Acta Ophthalmol. 2018;96(4):356–63.
doi: 10.1111/aos.13694
pubmed: 29575599
Sun M, Birkenfeld J, de Castro A, Ortiz S, Marcos S. OCT 3-D surface topography of isolated human crystalline lenses. Biomed Opt Express. 2014;5(10):3547–61.
doi: 10.1364/BOE.5.003547
pubmed: 25360371
pmcid: 4206323
Pérez-Merino P, Velasco-Ocana M, Martinez-Enriquez E, Marcos S. OCT-based crystalline lens topography in accommodating eyes. Biomed Opt Express. 2015;6(12):5039–54.
doi: 10.1364/BOE.6.005039
pubmed: 26713216
pmcid: 4679276
Wu X, Chen L, Li Z, Zhao YE. Correlation Between Lens Density Measured by Swept-Source Optical Coherence Tomography and Phacodynamic Parameters of Centurion Phacoemulsification. Curr Eye Res. 2023;48(7):651–9.
Chen D, Li Z, Huang J, Yu L, Liu S, Zhao YE. Lens nuclear opacity quantitation with long-range swept-source optical coherence tomography: correlation to LOCS III and a Scheimpflug imaging-based grading system. Br J Ophthalmol. 2019;103(8):1048–53.
doi: 10.1136/bjophthalmol-2018-312661
pubmed: 30315132
Wong AL, Leung CK, Weinreb RN, Cheng AK, Cheung CY, Lam PT, Pang CP, Lam DS. Quantitative assessment of lens opacities with anterior segment optical coherence tomography. Br J Ophthalmol. 2009;93(1):61–5.
doi: 10.1136/bjo.2008.137653
pubmed: 18838411
Aly MG, Shams A, Fouad YA, Hamza I. Effect of lens thickness and nuclear density on the amount of laser fragmentation energy delivered during femtosecond laser-assisted cataract surgery. J Cataract Refract Surg. 2019;45(4):485–9.
doi: 10.1016/j.jcrs.2018.11.014
pubmed: 30826239
Wiemer NG, Dubbelman M, Kostense PJ, Ringens PJ, Polak BC. The influence of diabetes mellitus type 1 and 2 on the thickness, shape, and equivalent refractive index of the human crystalline lens. Ophthalmology. 2008;115(10):1679–86.
doi: 10.1016/j.ophtha.2008.03.019
pubmed: 18486214
Drexler W, Baumgartner A, Findl O, Hitzenberger CK, Sattmann H, Fercher AF. Submicrometer precision biometry of the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1997;38(7):1304–13.
pubmed: 9191593
Cruysberg LP, Doors M, Verbakel F, Berendschot TT, De Brabander J, Nuijts RM. Evaluation of the Lenstar LS 900 non-contact biometer. Br J Ophthalmol. 2010;94(1):106–10.
doi: 10.1136/bjo.2009.161729
pubmed: 19692383
Lim SA, Hwang J, Hwang KY, Chung SH. Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems. J Cataract Refract Surg. 2014;40(5):716–21.
doi: 10.1016/j.jcrs.2013.10.032
pubmed: 24767907