Irreversible electroporation promotes a pro-inflammatory tumor microenvironment and anti-tumor immunity in a mouse pancreatic cancer model.

Pancreatic cancer is a significant cause of cancer-related mortality and often presents with limited treatment options. Pancreatic tumors are also notorious for their immunosuppressive microenvironment. Irreversible electroporation (IRE) is a non-thermal tumor ablation modality that employs high-voltage microsecond pulses to transiently permeabilize cell membranes, ultimately inducing cell death. However, the understanding of IRE's impact beyond the initiation of focal cell death in tumor tissue remains limited. In this study, we demonstrate that IRE triggers a unique mix of cell death pathways and orchestrates a shift in the local tumor microenvironment driven, in part, by reducing the myeloid-derived suppressor cell (MDSC) and regulatory T cell populations and increasing cytotoxic T lymphocytes and neutrophils. We further show that IRE drives induce cell cycle arrest at the G0/G1 phase

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Copyright © 2024 Imran, Brock, Beitel-White, Powar, Orr, Aycock, Alinezhadbalalami, Salameh, Eversole, Tintera, Markov Madanick, Hendricks-Wenger, Coutermarsh-Ott, Davalos and Allen.

Déclaration de conflit d'intérêts

IA, and RD are inventors on pending and issued patents related to the work. The authors declare no additional conflicts of interest. IA and RD have had projects supported, in part, by industry funding from business entities utilizing or developing IRE-based technologies for commercial applications. Those relevant to the current study include AngioDynamics, Galvanize Therapeutics, and ManaMed Tech. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.