[Effectiveness and safety of biological therapy in patients with severe asthma in a real clinical practice].

To assess effectiveness and safety of biological therapy in patients with severe asthma during 5 yr follow-up. We recruited 129 adult outpatients (29% males) aged 18-81 yrs with severe asthma were followed up during 5 yrs and were examined for every 3-6 months. Eighty five patients were treated by conventional therapy (ICS/LABA ± tiotropium, montelukast, OCS) only and 44 pts additionally received biologicals (оmalizumab - 9 pts, мepolizumab - 8 pts, benralizumab - 11 pts, dupilumab - 16 pts). Pulmonary function tests were measured by dry spirometer (2120, Vitalograph Ltd., UK). Eosinophil count in blood was assessed by automatic haemoanalyser. Fraction of exhaled nitric oxide was measured by a chemiluminescence analyzer (LR4100; Logan Research, UK). Asthma control and quality of life were assessed by using Russian versions of ACQ-5 and SGRQ. The use of biologicals led to a more significant reduction of exacerbations and OCS use, improvement of lung function, asthma control and quality of life, decrease of eosinophil and fraction of exhaled nitric oxide than conventional therapy of severe asthma ( Long-term use of biologicals added to conventional therapy in patients with severe asthma is characterized by high effectiveness and favorable safety profile. Цель. Провести оценку эффективности и безопасности препаратов моноклональных антител у пациентов с тяжелой бронхиальной астмой (ТБА) в пятилетнем проспективном наблюдении. Материалы и методы. Всего 129 взрослых амбулаторных пациентов (мужчин 29%) с ТБА в возрасте от 18 до 81 года обследованы в течение 5 лет с интервалами 3–6 мес. Стандартную терапию (ингаляционные глюкокортикостероиды / длительно действующие b