Synapsin E-domain is essential for α-synuclein function.
alpha-synuclein
cell biology
mouse
neuroscience
presynaptic
synapsin
synaptic terminals
synaptic transmission
synaptic vesicles
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
07 May 2024
07 May 2024
Historique:
medline:
7
5
2024
pubmed:
7
5
2024
entrez:
7
5
2024
Statut:
epublish
Résumé
The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here, we identify the synapsin E-domain as an essential functional binding-partner of α-synuclein (α-syn). Synapsin E-domain allows α-syn functionality, binds to α-syn, and is necessary and sufficient for enabling effects of α-syn at synapses of cultured mouse hippocampal neurons. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters.
Identifiants
pubmed: 38713200
doi: 10.7554/eLife.89687
pii: 89687
doi:
pii:
Substances chimiques
alpha-Synuclein
0
Synapsins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01NS111978
Pays : United States
Organisme : NINDS NIH HHS
ID : P30NS047101
Pays : United States
Informations de copyright
© 2023, Stavsky, Parra-Rivas et al.
Déclaration de conflit d'intérêts
AS, LP, ST, JR, KM, SR, DG No competing interests declared