Molecular characterization of influenza virus circulating in Nepal in the year 2019.
Humans
Nepal
/ epidemiology
Influenza, Human
/ epidemiology
Female
Male
Child
Adult
Adolescent
Middle Aged
Child, Preschool
Infant
Retrospective Studies
Young Adult
Cross-Sectional Studies
Aged
Influenza B virus
/ genetics
Seasons
Influenza A Virus, H1N1 Subtype
/ genetics
Influenza A Virus, H3N2 Subtype
/ genetics
Influenza
Lineage and pandemic
RT PCR
Strain
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 May 2024
07 May 2024
Historique:
received:
15
12
2023
accepted:
02
04
2024
medline:
8
5
2024
pubmed:
8
5
2024
entrez:
7
5
2024
Statut:
epublish
Résumé
Influenza (sometimes referred to as "flu") is a contagious viral infection of the airways in the lungs that affects a significant portion of the world's population. Clinical symptoms of influenza virus infections can range widely, from severe pneumonia to moderate or even asymptomatic sickness. If left untreated, influenza can have more severe effects on the heart, brain, and lungs than on the respiratory tract and can necessitate hospitalization. This study was aimed to investigate and characterize all types of influenza cases prevailing in Nepal and to analyze seasonal occurrence of Influenza in Nepal in the year 2019. A cross sectional, retrospective and descriptive study was carried out at National Influenza Center (NIC), National Public Health Laboratory Kathmandu Nepal for the period of one year (Jan-Dec 2019). A total of 3606 throat swab samples from various age groups and sexes were processed at the NIC. The specimens were primarily stored at 4 °C and processed using ABI 7500 RT PCR system for the identification of Influenza virus types and subtypes. Data accessed for research purpose were retrieved from National Influenza Centre (NIC) on 1st Jan 2020. Of the total 3606 patients suspected of having influenza infection, influenza viruses were isolated from 1213 (33.6%) patients with male predominance. The highest number of infection was caused by Influenza A/Pdm09 strain 739 (60.9%) followed by Influenza B 304 (25.1%) and Influenza A/H3 169 (13.9%) and most remarkable finding of this study was the detection of H5N1 in human which is the first ever case of such infection in human from Nepal. Similar to other tropical nations, influenza viruses were detected year-round in various geographical locations of Nepal. The influenza virus type and subtypes that were in circulation in Nepal were comparable to vaccine candidate viruses, which the currently available influenza vaccine may prevent.
Identifiants
pubmed: 38714669
doi: 10.1038/s41598-024-58676-6
pii: 10.1038/s41598-024-58676-6
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10436Informations de copyright
© 2024. The Author(s).
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https://www.who.int/nepal/news/detail/01-05-2019-information-on-avian-influenza-a-(h5n1)-identified-in-human-in-nepal