Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
07 May 2024
07 May 2024
Historique:
received:
04
11
2023
accepted:
15
04
2024
medline:
8
5
2024
pubmed:
8
5
2024
entrez:
7
5
2024
Statut:
epublish
Résumé
The Wnt-planar cell polarity (Wnt-PCP) pathway is crucial in establishing cell polarity during development and tissue homoeostasis. This pathway is found to be dysregulated in many pathological conditions, including cancer and autoimmune disorders. The central event in Wnt-PCP pathway is the activation of Weak-similarity guanine nucleotide exchange factor (WGEF) by the adapter protein Dishevelled (Dvl). The PDZ domain of Dishevelled2 (Dvl2
Identifiants
pubmed: 38714795
doi: 10.1038/s42003-024-06194-6
pii: 10.1038/s42003-024-06194-6
doi:
Substances chimiques
Dishevelled Proteins
0
Guanine Nucleotide Exchange Factors
0
DVL2 protein, human
0
Peptides
0
CCDC88C protein, human
0
Microfilament Proteins
0
Intracellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
543Informations de copyright
© 2024. The Author(s).
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