Agar-tragacanth/silk fibroin hydrogel containing Zn-based MOF as a novel nanobiocomposite with biological activity.
Fibroins
/ chemistry
Humans
Hydrogels
/ chemistry
Agar
/ chemistry
Nanocomposites
/ chemistry
Tragacanth
/ chemistry
Escherichia coli
/ drug effects
Staphylococcus aureus
/ drug effects
HEK293 Cells
Zinc
/ chemistry
Cell Proliferation
/ drug effects
Anti-Bacterial Agents
/ pharmacology
Metal-Organic Frameworks
/ chemistry
Microbial Sensitivity Tests
MCF-7 Cells
Cell Line, Tumor
Agar
Biological activity
MOF-5
Silk fibroin
Tragacanth gum
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 May 2024
07 May 2024
Historique:
received:
14
11
2023
accepted:
03
05
2024
medline:
8
5
2024
pubmed:
8
5
2024
entrez:
7
5
2024
Statut:
epublish
Résumé
In this study, a novel nanobiocomposite consisting of agar (Ag), tragacanth gum (TG), silk fibroin (SF), and MOF-5 was synthesized and extensively investigated by various analytical techniques and basic biological assays for potential biomedical applications. The performed Trypan blue dye exclusion assay indicated that the proliferation percentage of HEK293T cells was 71.19%, while the proliferation of cancer cells (K-562 and MCF-7) was significantly lower, at 10.74% and 3.33%. Furthermore, the Ag-TG hydrogel/SF/MOF-5 nanobiocomposite exhibited significant antimicrobial activity against both E. coli and S. aureus strains, with growth inhibition rates of 76.08% and 69.19% respectively. Additionally, the hemolytic index of fabricated nanobiocomposite was found approximately 19%. These findings suggest that the nanobiocomposite exhibits significant potential for application in cancer therapy and wound healing.
Identifiants
pubmed: 38714808
doi: 10.1038/s41598-024-61329-3
pii: 10.1038/s41598-024-61329-3
doi:
Substances chimiques
Fibroins
9007-76-5
Hydrogels
0
Agar
9002-18-0
Tragacanth
9000-65-1
Zinc
J41CSQ7QDS
Anti-Bacterial Agents
0
Metal-Organic Frameworks
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10508Informations de copyright
© 2024. The Author(s).
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