Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms.


Journal

Nature biotechnology
ISSN: 1546-1696
Titre abrégé: Nat Biotechnol
Pays: United States
ID NLM: 9604648

Informations de publication

Date de publication:
07 May 2024
Historique:
received: 07 11 2023
accepted: 02 04 2024
medline: 8 5 2024
pubmed: 8 5 2024
entrez: 7 5 2024
Statut: aheadofprint

Résumé

A central challenge in developing personalized cancer cell immunotherapy is the identification of tumor-reactive T cell receptors (TCRs). By exploiting the distinct transcriptomic profile of tumor-reactive T cells relative to bystander cells, we build and benchmark TRTpred, an antigen-agnostic in silico predictor of tumor-reactive TCRs. We integrate TRTpred with an avidity predictor to derive a combinatorial algorithm of clinically relevant TCRs for personalized T cell therapy and benchmark it in patient-derived xenografts.

Identifiants

pubmed: 38714897
doi: 10.1038/s41587-024-02232-0
pii: 10.1038/s41587-024-02232-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Rémy Pétremand (R)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Johanna Chiffelle (J)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Sara Bobisse (S)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Marta A S Perez (MAS)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Molecular Modelling Group, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.

Julien Schmidt (J)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.
Center of Experimental Therapeutics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Marion Arnaud (M)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

David Barras (D)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Maria Lozano-Rabella (M)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Raphael Genolet (R)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Christophe Sauvage (C)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Damien Saugy (D)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Alexandra Michel (A)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Anne-Laure Huguenin-Bergenat (AL)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Charlotte Capt (C)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Jonathan S Moore (JS)

Department of Medicine and Center of Translational Research in Onco-Hematology, Faculty of Medicine, University of Geneva, Swiss Cancer Center Leman, Geneva, Switzerland.

Claudio De Vito (C)

Division of Clinical Pathology, Department of Diagnostics, Hôpitaux Universitaires de Genève, Geneva, Switzerland.

S Intidhar Labidi-Galy (SI)

Department of Medicine and Center of Translational Research in Onco-Hematology, Faculty of Medicine, University of Geneva, Swiss Cancer Center Leman, Geneva, Switzerland.
Department of Oncology, Hôpitaux Universitaires de Genève, Geneva, Switzerland.

Lana E Kandalaft (LE)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.
Center of Experimental Therapeutics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Denarda Dangaj Laniti (D)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.

Michal Bassani-Sternberg (M)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.
Center of Experimental Therapeutics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Giacomo Oliveira (G)

Dana-Farber Cancer Institute, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Catherine J Wu (CJ)

Dana-Farber Cancer Institute, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

George Coukos (G)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland.
Immuno-oncology Service, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.

Vincent Zoete (V)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland.
Molecular Modelling Group, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.

Alexandre Harari (A)

Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland. alexandre.harari@chuv.ch.
Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland. alexandre.harari@chuv.ch.

Classifications MeSH