Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer.


Journal

Molecular cancer
ISSN: 1476-4598
Titre abrégé: Mol Cancer
Pays: England
ID NLM: 101147698

Informations de publication

Date de publication:
07 May 2024
Historique:
received: 12 06 2023
accepted: 02 04 2024
medline: 8 5 2024
pubmed: 8 5 2024
entrez: 7 5 2024
Statut: epublish

Résumé

Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional therapy. Immunotherapy is crucial for treating metastatic breast cancer, but its resistance is a major limitation. The tumor microenvironment (TME) is vital in modulating the immunotherapy response. Various tumor microenvironmental components, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs), are involved in TME modulation to cause immunotherapy resistance. This review highlights the role of stromal cells in modulating the breast tumor microenvironment, including the involvement of CAF-TAM interaction, alteration of tumor metabolism leading to immunotherapy failure, and other latest strategies, including high throughput genomic screening, single-cell and spatial omics techniques for identifying tumor immune genes regulating immunotherapy response. This review emphasizes the therapeutic approach to overcome breast cancer immune resistance through CAF reprogramming, modulation of TAM polarization, tumor metabolism, and genomic alterations.

Identifiants

pubmed: 38715072
doi: 10.1186/s12943-024-01990-4
pii: 10.1186/s12943-024-01990-4
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

92

Subventions

Organisme : DST INSPIRE Fellowship Program
ID : DST/INSPIRE Fellowship/2021/IF210059
Organisme : DBT-BUILDER Program, Govt. of India
ID : BT/INF/22/SP42155/2021
Organisme : Science and Engineering Research Board (SERB) Program, Govt. of India
ID : Project/Grant No. JCB/2023/000011
Organisme : Department of Biotechnology (DBT) Program, Govt of India
ID : Project/Grant No. BT/PR-32388/TRM/120/242/2019

Informations de copyright

© 2024. The Author(s).

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Auteurs

Moumita Kundu (M)

School of Biotechnology, KIIT Deemed to be University, Bhubaneswar, 751024, India.
Department of Pharmaceutical Technology, Brainware University, West Bengal, 700125, India.

Ramesh Butti (R)

Department of Internal Medicine, Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.

Venketesh K Panda (VK)

School of Biotechnology, KIIT Deemed to be University, Bhubaneswar, 751024, India.

Diksha Malhotra (D)

School of Biotechnology, KIIT Deemed to be University, Bhubaneswar, 751024, India.

Sumit Das (S)

National Centre for Cell Sciences, Savitribai Phule Pune University Campus, Pune, 411007, India.

Tandrima Mitra (T)

School of Biotechnology, KIIT Deemed to be University, Bhubaneswar, 751024, India.

Prachi Kapse (P)

School of Basic Medical Sciences, Savitribai Phule Pune University, Pune, 411007, India.

Suresh W Gosavi (SW)

School of Basic Medical Sciences, Savitribai Phule Pune University, Pune, 411007, India.

Gopal C Kundu (GC)

School of Biotechnology, KIIT Deemed to be University, Bhubaneswar, 751024, India. gopalc.kundu@kiit.ac.in.
Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, 751024, India. gopalc.kundu@kiit.ac.in.

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