Longitudinal in vivo cationic contrast-enhanced computed tomography classifies equine articular cartilage injury and repair.
CT
biomarker
glycosaminoglycan
imaging
osteoarthritis
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ISSN: 1554-527X
Titre abrégé: J Orthop Res
Pays: United States
ID NLM: 8404726
Informations de publication
Date de publication:
08 May 2024
08 May 2024
Historique:
revised:
12
03
2024
received:
30
12
2023
accepted:
23
04
2024
medline:
8
5
2024
pubmed:
8
5
2024
entrez:
8
5
2024
Statut:
aheadofprint
Résumé
Cationic contrast-enhanced computed tomography (CECT) capitalizes on increased contrast agent affinity to the charged proteoglycans in articular cartilage matrix to provide quantitative assessment of proteoglycan content with enhanced images. While high resolution microCT has demonstrated success, we investigate cationic CECT use in longitudinal in vivo imaging at clinical resolution. We hypothesize that repeated administration of CA4+ will have no adverse side effects or complications, and that sequential in vivo imaging assessments will distinguish articular cartilage repair tissue from early degenerative and healthy cartilage in critically sized chondral defects. In an established equine translational preclinical model, lameness and synovial effusion scores are similar to controls after repeated injections of CA4+ (eight injections over 16 weeks) compared to controls. Synovial fluid total protein, leukocyte concentration, and sGAG and PGE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Päivikki ja Sakari Sohlbergin Säätiö
Organisme : Suomen Kulttuurirahasto
Organisme : Grayson-Jockey Club Research Foundation
Organisme : College of Veterinary Medicine and Biomedical Sciences Cooperative Veterinary Scientist Research Training Fellowship, Colorado State University
Organisme : William Fairfield Warren Distinguished Professorship
Organisme : Orion Research Foundation
Organisme : Finnish Cultural Foundation
Informations de copyright
© 2024 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.
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