Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis.

Animals Homeostasis Membrane Proteins / genetics Mice Mice, Knockout Sphingolipids / metabolism B-Lymphocytes / immunology Gene Deletion Mice, Inbred C57BL Spleen / immunology
B cells ORMDL proteins lymphocyte sphingolipids spleen

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2024
Historique:
received: 25 01 2024
accepted: 08 04 2024
medline: 8 5 2024
pubmed: 8 5 2024
entrez: 8 5 2024
Statut: epublish

Résumé

ORMDL3 is a prominent member of a family of highly conserved endoplasmic reticulum resident proteins, ORMs (ORM1 and ORM2) in yeast, dORMDL in

Identifiants

DOI: 10.3389/fimmu.2024.1376629 PMID: 38715613 PMC: PMC11074395
pubmed: 38715613
doi: 10.3389/fimmu.2024.1376629
pmc: PMC11074395
doi:

Substances chimiques

Membrane Proteins 0
ORMDL3 protein, mouse 0
Sphingolipids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1376629

Informations de copyright

Copyright © 2024 Demkova, Bugajev, Adamcova, Kuchar, Grusanovic, Alberich-Jorda, Draber and Halova.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Livia Demkova (L)

Laboratory of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

Viktor Bugajev (V)

Laboratory of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

Miroslava K Adamcova (MK)

Laboratory of Hemato-Oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

Ladislav Kuchar (L)

Research Unit for Rare Diseases, Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.

Srdjan Grusanovic (S)

Laboratory of Hemato-Oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

Meritxell Alberich-Jorda (M)

Laboratory of Hemato-Oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

Petr Draber (P)

Laboratory of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

Ivana Halova (I)

Laboratory of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Lipides › Lipides membranaires › Sphingolipides › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Simultaneous deletion of ORMDL1 and ORMDL3...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › Simultaneous deletion of ORMDL1 and ORMDL3...