Macrophage/microglia-producing transient increase of platelet-activating factor is involved in neuropathic pain.

Cell biology Immunology Neuroscience

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
19 Apr 2024
Historique:
received: 10 09 2023
revised: 24 01 2024
accepted: 07 03 2024
medline: 8 5 2024
pubmed: 8 5 2024
entrez: 8 5 2024
Statut: epublish

Résumé

Peripheral nerve injury (PNI) induces debilitating neuropathic pain symptoms, such as tactile allodynia. Accumulating evidence suggests that the expression levels of various transcripts and proteins are drastically changed after PNI. Recent lipidome analysis demonstrates increased levels of diverse lipids in chronic pain conditions. We show that PNI transiently increases platelet-activating factor (PAF) levels, a potent inflammatory phospholipid mediator, in the dorsal root ganglia (DRG) and spinal cord. We revealed that macrophage and microglia-specific PAF-producing enzyme LPLAT9/LPCAT2 knockout mice (

Identifiants

DOI: 10.1016/j.isci.2024.109466 PMID: 38715939 PMC: PMC11074981
pubmed: 38715939
doi: 10.1016/j.isci.2024.109466
pii: S2589-0042(24)00687-4
pmc: PMC11074981
doi:

Types de publication

Journal Article

Langues

eng

Pagination

109466

Informations de copyright

© 2024 The Author(s).

Déclaration de conflit d'intérêts

The authors declare that they have no competing interests.

Auteurs

Shota Yamamoto (S)

Department of Lipid Life Science, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.
Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.

Tomomi Hashidate-Yoshida (T)

Department of Lipid Life Science, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.

Yuki Yoshinari (Y)

Department of Lipid Life Science, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.
Graduate School of Life Sciences, Showa Women's University, Setagaya-ku, Tokyo, Japan.

Takao Shimizu (T)

Department of Lipid Signaling, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.
Institute of Microbial Chemistry, Setagaya-ku, Tokyo, Japan.

Hideo Shindou (H)

Department of Lipid Life Science, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.
Department of Medical Lipid Science, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Classifications MeSH