Unlocking the potential of Molecular Tumor Boards: from cutting-edge data interpretation to innovative clinical pathways.

The emerging era of precision medicine is characterized by an increasing availability of targeted anticancer therapies and by the parallel development of techniques to obtain more refined molecular data, whose interpretation may not always be straightforward. Molecular tumor boards gather various professional figures, in order to leverage the analysis of molecular data and provide prognostic and predictive insights for clinicians. In addition to healthcare development, they could also become a tool to promote knowledge and research spreading. A growing body of evidence on the application of molecular tumor boards to clinical practice is forming and positive signals are emerging, although a certain degree of heterogeneity exists. This work analyzes molecular tumor boards' potential workflows, figures involved, data sources, sample matrices and eligible patients, as well as available evidence and learning examples. The emerging concept of multi-institutional, disease-specific molecular tumor boards is also considered by presenting two ongoing nationwide experiences.

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Copyright © 2024. Published by Elsevier B.V.

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Declaration of Competing Interest Giulia Buzzatti reports personal fees for consultancy/advisory role from Novartis, Eli Lilly and AstraZeneca. Umberto Malapelle reports personal fees for consultancy/advisory role from Boehringer Ingelheim, Roche, MSD, Amgen, ThermoFisher Scientific, Eli Lilly, Diaceutics, GlaxoSmithKline, Merck and AstraZeneca; personal fees for speakers’ bureau from Boehringer Ingelheim, AstraZeneca, Roche, MSD, Amgen, Merck, ThermoFisher Scientific, Eli Lilly, Diaceutics, GlaxoSmithKline and QIAGEN. Carmine De Angelis reports personal fees as consultant and/or speakers' bureau from Roche, Eli Lilly, GSK, Novartis, Pfizer, AstraZeneca, Gilead and Seagen; research grant to the Institution from Novartis. Maria Vittoria Dieci reports personal fees for consultancy/advisory role from Eli Lilly, Exact Sciences, Novartis, Pfizer, Seagen, Gilead, MSD, AstraZeneca, Daiichi Sankyo and Roche. Matteo Lambertini reports personal fees for advisory role from Roche, Eli Lilly, Novartis, AstraZeneca, Pfizer, Seagen, Gilead, MSD and Exact Sciences; speaker honoraria from Roche, Eli Lilly, Novartis, Pfizer, Sandoz, Libbs, Daiichi Sankyo and Takeda; travel grants from Gilead; research support (to the Institution) from Gilead. Angela Toss reports personal fees for consultancy/advisory role from Eli Lilly, Novartis, Pfizer, Seagen, Gilead, MSD, AstraZeneca and Daiichi Sankyo. Alberto Farolfi reports personal fees for consultancy/advisory role from AstraZeneca, GSK-Tesaro, Clovis and Janssen. Sandro Pignata reports speaker honoraria from AstraZeneca, Roche, PharmaMar, Tesaro, Pfizer and MSD; personal fees for consultancy/advisory role from AstraZeneca, Roche, PharmaMar, Pfizer, Tesaro and Clovis Oncology; research funding (to the Institution) from Roche, AstraZeneca, MSD and Pfizer. Michele Bartoletti reports personal fees for advisory board from GSK, MSD and EISAI; speaker fees from GSK and AstraZeneca; research grant from AstraZeneca and Roche; data monitoring committee for Novartis. Lorenzo Gerratana reports advisory/consultancy fees from AstraZeneca, Daiichi Sankyo, Eli Lilly, GlaxoSmithKline, Incyte, Novartis, Pfizer, MSD, Menarini Stemline, Abbvie; research funding from Menarini Silicon Biosystems; travel expenses from Menarini Stemline. Fabio Puglisi reports speaker honoraria from Roche, MSD, AstraZeneca, Novartis, Pierre Fabre, Daiichi Sankyo, Eisai, Eli Lilly, Pfizer and Exact Sciences; consulting or advisory role for Roche, Amgen, Novartis, Pfizer, Eisai, Seagen, Pierre Fabre, AstraZeneca/Daiichi Sankyo, Viatris, Eli Lilly, Gilead Sciences and Daiichi Sankyo Europe GmbH; research funding (to the Institution) from Eisai, AstraZeneca and Roche; travel and accommodation expenses fees from Roche, Celgene, GlaxoSmithKline, Amgen, AstraZeneca, MSD, Novartis, Eli Lilly and Pfizer. All reported potential conflicts of interest are outside the submitted work. All other authors have declared no potential conflicts of interests.