Trim66's paternal deficiency causes intrauterine overgrowth.

Animals Male Mice Female Histones / metabolism Mice, Knockout Spermatids / metabolism Spermatozoa / metabolism Spermatogenesis / genetics Transcription Factors / genetics Phenotype Paternal Inheritance / genetics Mutation Methylation Mice, Inbred C57BL Acetylation

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
Jul 2024
Historique:
received: 06 12 2023
revised: 24 04 2024
accepted: 25 04 2024
medline: 9 5 2024
pubmed: 9 5 2024
entrez: 8 5 2024
Statut: epublish

Résumé

The tripartite motif-containing protein 66 (TRIM66, also known as TIF1-delta) is a PHD-Bromo-containing protein primarily expressed in post-meiotic male germ cells known as spermatids. Biophysical assays showed that the TRIM66 PHD-Bromodomain binds to H3 N-terminus only when lysine 4 is unmethylated. We addressed TRIM66's role in reproduction by loss-of-function genetics in the mouse. Males homozygous for

Identifiants

DOI: 10.26508/lsa.202302512 PMID: 38719749
pubmed: 38719749
pii: 7/7/e202302512
doi: 10.26508/lsa.202302512
pii:
doi:

Substances chimiques

Histones 0
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 Mielnicka et al.

Auteurs

Monika Mielnicka (M)

https://ror.org/01yr73893 Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Monterotondo, Italy.
ORCID: 0000-0002-2306-7254

Francesco Tabaro (F)

https://ror.org/01yr73893 Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Monterotondo, Italy.
ORCID: 0000-0002-7559-5585

Rahul Sureka (R)

https://ror.org/01yr73893 Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Monterotondo, Italy.
ORCID: 0000-0002-6743-5266

Basilia Acurzio (B)

https://ror.org/01yr73893 Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Monterotondo, Italy.
ORCID: 0000-0002-4703-8511

Renata Paoletti (R)

Plaisant s.r.l., Rome, Italy.

Ferdinando Scavizzi (F)

National Research Council (IBBC), CNR-Campus International Development (EMMA-INFRAFRONTIER-IMPC), Monterotondo, Italy.
ORCID: 0000-0002-4483-6753

Marcello Raspa (M)

National Research Council (IBBC), CNR-Campus International Development (EMMA-INFRAFRONTIER-IMPC), Monterotondo, Italy.

Alvaro H Crevenna (AH)

https://ror.org/01yr73893 Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Monterotondo, Italy.
ORCID: 0000-0002-5580-3711

Karine Lapouge (K)

https://ror.org/01yr73893 European Molecular Biology Laboratory, Protein Expression and Purification Core Facility, Heidelberg, Germany.
ORCID: 0000-0003-0620-9553

Kim Remans (K)

https://ror.org/01yr73893 European Molecular Biology Laboratory, Protein Expression and Purification Core Facility, Heidelberg, Germany.
ORCID: 0000-0002-4394-7953

Matthieu Boulard (M)

https://ror.org/01yr73893 Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Monterotondo, Italy matthieu.boulard@embl.it.
ORCID: 0000-0001-5135-8529

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Trim66's paternal deficiency causes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Trim66's paternal deficiency causes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Trim66's paternal deficiency causes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Trim66's paternal deficiency causes...
questionsmedicales.fr › Cellules › Cellules germinales › Spermatozoïdes › Spermatides › Trim66's paternal deficiency causes...
questionsmedicales.fr › Cellules › Cellules germinales › Spermatozoïdes › Trim66's paternal deficiency causes...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Gamétogenèse › Spermatogenèse › Trim66's paternal deficiency causes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Trim66's paternal deficiency causes...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Trim66's paternal deficiency causes...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité paternelle › Trim66's paternal deficiency causes...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Trim66's paternal deficiency causes...
questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › Trim66's paternal deficiency causes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Trim66's paternal deficiency causes...
questionsmedicales.fr › Métabolisme › Acylation › Acétylation › Trim66's paternal deficiency causes...