Peptides and metal ions: A successful marriage for developing artificial metalloproteins.
artificial enzymes
catalysis
de novo design
electron transfer
metal ions
metalloprotein models
peptides
Journal
Journal of peptide science : an official publication of the European Peptide Society
ISSN: 1099-1387
Titre abrégé: J Pept Sci
Pays: England
ID NLM: 9506309
Informations de publication
Date de publication:
08 May 2024
08 May 2024
Historique:
revised:
27
03
2024
received:
19
02
2024
accepted:
28
03
2024
medline:
9
5
2024
pubmed:
9
5
2024
entrez:
8
5
2024
Statut:
aheadofprint
Résumé
The mutual relationship between peptides and metal ions enables metalloproteins to have crucial roles in biological systems, including structural, sensing, electron transport, and catalytic functions. The effort to reproduce or/and enhance these roles, or even to create unprecedented functions, is the focus of protein design, the first step toward the comprehension of the complex machinery of nature. Nowadays, protein design allows the building of sophisticated scaffolds, with novel functions and exceptional stability. Recent progress in metalloprotein design has led to the building of peptides/proteins capable of orchestrating the desired functions of different metal cofactors. The structural diversity of peptides allows proper selection of first- and second-shell ligands, as well as long-range electrostatic and hydrophobic interactions, which represent precious tools for tuning metal properties. The scope of this review is to discuss the construction of metal sites in de novo designed and miniaturized scaffolds. Selected examples of mono-, di-, and multi-nuclear binding sites, from the last 20 years will be described in an effort to highlight key artificial models of catalytic or electron-transfer metalloproteins. The authors' goal is to make readers feel like guests at the marriage between peptides and metal ions while offering sources of inspiration for future architects of innovative, artificial metalloproteins.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3606Subventions
Organisme : Italian Ministry of University and Research (MUR) "Dipartimenti di Eccellenza 2023-2027" program, arCHIMede project
ID : E63C22003710006
Organisme : Programma Operativo Nazionale Ricerca e Innovazione (PON R&I)
ID : E65F21003010003
Organisme : Programma Operativo Nazionale Ricerca e Innovazione (PON R&I)
ID : E65F21003750003
Organisme : European Research Council (ERC), UGOV 000005_HORIZON2020_ERC_2018_BioDisOrder Project
ID : E64I19002960006
Organisme : Italian Ministry of University and Research (MUR), PRIN2020 program, Project SEAWAVE 2020BKK3W9
ID : E69J22001140005
Organisme : CRUI-CARE WILEY Agreement with University of Naples Federico II
Informations de copyright
© 2024 European Peptide Society and John Wiley & Sons Ltd.
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