Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK.

COVID-19 HBV epidemiology hepatitis B virus viral hepatitis virology

Journal

Wellcome open research
ISSN: 2398-502X
Titre abrégé: Wellcome Open Res
Pays: England
ID NLM: 101696457

Informations de publication

Date de publication:
2022
Historique:
accepted: 14 11 2023
medline: 9 5 2024
pubmed: 9 5 2024
entrez: 9 5 2024
Statut: epublish

Résumé

To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used for routine surveillance (alanine transferase [ALT] and HBV viral load). We used anonymized electronic health record data from the National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) pipeline representing five UK National Health Service (NHS) Trusts. We report significant reductions in surveillance of both biomarkers during the pandemic compared to pre-COVID-19 years, both in terms of the proportion of patients who had ≥1 measurement annually, and the mean number of measurements per patient. These results demonstrate the real-time utility of HIC data in monitoring health-care provision, and support interventions to provide catch-up services to minimise the impact of the pandemic. Further investigation is required to determine whether these disruptions will be associated with increased rates of adverse chronic HBV outcomes.

Sections du résumé

Background UNASSIGNED
To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used for routine surveillance (alanine transferase [ALT] and HBV viral load).
Methods UNASSIGNED
We used anonymized electronic health record data from the National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) pipeline representing five UK National Health Service (NHS) Trusts.
Results UNASSIGNED
We report significant reductions in surveillance of both biomarkers during the pandemic compared to pre-COVID-19 years, both in terms of the proportion of patients who had ≥1 measurement annually, and the mean number of measurements per patient.
Conclusions UNASSIGNED
These results demonstrate the real-time utility of HIC data in monitoring health-care provision, and support interventions to provide catch-up services to minimise the impact of the pandemic. Further investigation is required to determine whether these disruptions will be associated with increased rates of adverse chronic HBV outcomes.

Identifiants

DOI: 10.12688/wellcomeopenres.17522.2 PMID: 38721280 PMC: PMC11077619
pubmed: 38721280
doi: 10.12688/wellcomeopenres.17522.2
pmc: PMC11077619
doi:

Types de publication

Journal Article

Langues

eng

Pagination

51

Informations de copyright

Copyright: © 2023 Campbell C et al.

Déclaration de conflit d'intérêts

Competing interests: GC reports personal fees from Gilead and Merck Sharp & Dohme outside the submitted work. BG reports other from Imperial National Institute for Health Research (NIHR) Biomedical Research Centres (BRC), during the conduct of the study. EN reports grants from ViiV healthcare, grants from GlaxoSmithKline (GSK), grants from Gilead, outside the submitted work. Other authors have no conflict of interest.

Auteurs

Cori Campbell (C)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
ORCID: 0000-0001-5890-7105

Tingyan Wang (T)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
ORCID: 0000-0002-8351-9494

David A Smith (DA)

NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
ORCID: 0000-0001-7778-7137

Oliver Freeman (O)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Theresa Noble (T)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Kinga A Várnai (KA)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
ORCID: 0000-0001-5695-9497

Steve Harris (S)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Department of Computer Science, University of Oxford, Oxford, UK.
ORCID: 0000-0002-0899-325X

Hizni Salih (H)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
ORCID: 0000-0002-5283-7799

Gail Roadknight (G)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
ORCID: 0000-0002-1158-0181

Stephanie Little (S)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Ben Glampson (B)

NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK.
NIHR Imperial Biomedical Research Centre, London, UK.

Luca Mercuri (L)

NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK.
NIHR Imperial Biomedical Research Centre, London, UK.
ORCID: 0000-0001-9076-5717

Dimitri Papadimitriou (D)

NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK.
NIHR Imperial Biomedical Research Centre, London, UK.

Christopher R Jones (CR)

Department of Infectious Disease, Imperial College London, London, UK.

Vince Taylor (V)

Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Afzal Chaudhry (A)

Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Hang Phan (H)

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Florina Borca (F)

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Josune Olza (J)

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
ORCID: 0000-0001-8840-8542

Frazer Warricker (F)

University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Luis Romão (L)

University College London Hospitals NHS Foundation Trust, London, UK.
ORCID: 0000-0001-5545-5289

David Ramlakhan (D)

University College London Hospitals NHS Foundation Trust, London, UK.

Louise English (L)

University College London Hospitals NHS Foundation Trust, London, UK.

Paul Klenerman (P)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Monique I Andersson (MI)

Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.
ORCID: 0000-0003-0619-1074

Jane Collier (J)

Department of Hepatology, John Radcliffe Hospital, Oxford, UK.

Eleni Nastouli (E)

Department of Clinical Virology, University College London Hospitals NHS Trust, London, UK.

Salim I Khakoo (SI)

School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

William Gelson (W)

Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Graham S Cooke (GS)

NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK.
NIHR Imperial Biomedical Research Centre, London, UK.
Faculty of Medicine, Department of Infectious Disease, Imperial College London, London, UK.
ORCID: 0000-0001-6475-5056

Kerrie Woods (K)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Jim Davies (J)

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Department of Computer Science, University of Oxford, Oxford, UK.

Eleanor Barnes (E)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.
NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
ORCID: 0000-0002-0860-0831

Philippa C Matthews (PC)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.
NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Classifications MeSH