Microbial chassis as the platform for production of dihydroxy xanthophyll-based carotenoids: an overview of recent advances in biomanufacturing.
Biomanufacturing
Biosynthesis
Lutein
Microbes
Xanthophylls
Zeaxanthin
Journal
World journal of microbiology & biotechnology
ISSN: 1573-0972
Titre abrégé: World J Microbiol Biotechnol
Pays: Germany
ID NLM: 9012472
Informations de publication
Date de publication:
09 May 2024
09 May 2024
Historique:
received:
24
02
2024
accepted:
19
04
2024
medline:
9
5
2024
pubmed:
9
5
2024
entrez:
9
5
2024
Statut:
epublish
Résumé
Physiological and environmental cues prompt microbes to synthesize diverse carotenoids, including dihydroxy xanthophylls, facilitating their adaptation and survival. Lutein and its isomeric counterpart, zeaxanthin, are notable dihydroxy xanthophylls with bioactive properties such as antioxidative, anti-inflammatory, anticancer, and neuroprotective effects, particularly beneficial for human ocular health. However, global natural resources for co-producing lutein and zeaxanthin are scarce, with zeaxanthin lacking commercial sources, unlike lutein sourced from marigold plants and microalgae. Traditionally, dihydroxy xanthophyll production primarily relies on petrochemical synthetic routes, with limited biological sourcing reported. Nonetheless, microbiological synthesis presents promising avenues as a commercial source, albeit challenged by low dihydroxy xanthophyll yield at high cell density. Strategies involving optimization of physical and chemical parameters are essential to achieve high-quality dihydroxy xanthophyll products. This overview briefly discusses dihydroxy xanthophyll biosynthesis and highlights recent advancements, discoveries, and industrial benefits of lutein and zeaxanthin production from microorganisms as alternative biofactories.
Identifiants
pubmed: 38722384
doi: 10.1007/s11274-024-03996-y
pii: 10.1007/s11274-024-03996-y
doi:
Substances chimiques
Lutein
X72A60C9MT
Zeaxanthins
0
Xanthophylls
0
Carotenoids
36-88-4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
197Subventions
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : BT/PB/Center/03/2011 - Phase II
Organisme : Biotechnology Industry Research Assistance Council
ID : BT/SB0078/02/19
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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