Cutaneous Superficial Basal Cell Carcinoma is a Basal Cell Carcinoma In Situ: Electron Microscopy of a Case Series of Basal Cell Carcinomas.
Basal cell carcinoma
Basal lamina
Carcinoma
Electron microscopy
In situ
Skin cancer
Superficial
Ultrastructure
Journal
Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450
Informations de publication
Date de publication:
09 May 2024
09 May 2024
Historique:
received:
20
02
2024
accepted:
26
03
2024
medline:
9
5
2024
pubmed:
9
5
2024
entrez:
9
5
2024
Statut:
aheadofprint
Résumé
Basal cell carcinoma (BCC) is the most common skin cancer. Skin cancers may present either as a non-invasive tumor or an invasive malignancy. The terminology of carcinoma in situ is used when the tumor is either just limited to epidermis or not present as single cells or nests in the dermis. However, currently the terminology superficial BCC is inappropriately used instead of BCC in situ when the skin cancer is limited to epidermis. In this study we compare the pathologic changes of superficial, nodular, and infiltrative BCCs using electron microscopy to identify the ultrastructural characteristics and validate the previously proposed terminology. Three cases of BCC (superficial BCC, nodular BCC, and infiltrative BCC) diagnosed by dermatopathologists at our institute were selected for review. Paraffin block tissues from these cases were sent for electron microscopy studies which demonstrated disruption of basal lamina in both nodular and infiltrative type of BCC, while it remains intact in BCC superficial type after extensive examination. Therefore, similar to other in situ skin cancers, there is no invasion of the neoplasm in superficial BCC into the dermis. Hence, the older term superficial BCC should be appropriately replaced with the newer terminology BCC in situ.
Identifiants
pubmed: 38722558
doi: 10.1007/s13555-024-01151-x
pii: 10.1007/s13555-024-01151-x
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2024. The Author(s).
Références
Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the US population, 2012. JAMA Dermatol. 2015;151(10):1081–6. https://doi.org/10.1001/jamadermatol.2015.1187 .
doi: 10.1001/jamadermatol.2015.1187
pubmed: 25928283
Staples M, Marks R, Giles G. Trends in the incidence of non-melanocytic skin cancer (NMSC) treated in Australia 1985–1995: are primary prevention programs starting to have an effect? Int J Cancer. 1998;78(2):144–8. https://doi.org/10.1002/(sici)1097-0215(19981005)78:2%3c144::aid-ijc3%3e3.0.co;2-z .
doi: 10.1002/(sici)1097-0215(19981005)78:2<144::aid-ijc3>3.0.co;2-z
pubmed: 9754642
Casey AS, Kennedy CE, Goldman GD. Mohs micrographic surgery: how ACMS fellowship directors practice. Dermatol Surg. 2009;35(5):747–56. https://doi.org/10.1111/j.1524-4725.2009.01124.x .
doi: 10.1111/j.1524-4725.2009.01124.x
pubmed: 19389108
Nestor MS, Zarraga MB. The incidence of nonmelanoma skin cancers and actinic keratoses in South Florida. J Clin Aesthet Dermatol. 2012;5(4):20–4.
pubmed: 22708003
pmcid: 3366443
Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol. 2012;166(5):1069–80. https://doi.org/10.1111/j.1365-2133.2012.10830.x .
doi: 10.1111/j.1365-2133.2012.10830.x
pubmed: 22251204
Gellin GA, Kopf AW, Garfunkel L. Basal cell epithelioma. Arch Dermatol. 1965;91:38–45. https://doi.org/10.1001/archderm.1965.01600070044004 .
doi: 10.1001/archderm.1965.01600070044004
pubmed: 14229596
Mehregan AH, Pinkus H. Intraepidermal epithelioma: a critical study. Cancer. 1964;17:609–36. https://doi.org/10.1002/1097-0142(196405)17:5%3c609::aid-cncr2820170510%3e3.0.co;2-l .
doi: 10.1002/1097-0142(196405)17:5<609::aid-cncr2820170510>3.0.co;2-l
pubmed: 14159809
Cameron MC, Lee E, Hibler BP, et al. Basal cell carcinoma: epidemiology; pathophysiology; clinical and histological subtypes; and disease associations. J Am Acad Dermatol. 2019;80(2):303–17. https://doi.org/10.1016/j.jaad.2018.03.060 .
doi: 10.1016/j.jaad.2018.03.060
pubmed: 29782900
Cohen PR. Cutaneous basal cell carcinoma in situ: a case series. Cureus. 2022;14(9):e29479. https://doi.org/10.7759/cureus.29479 .
doi: 10.7759/cureus.29479
pubmed: 36299923
pmcid: 9588167
Cohen PR. Basal cell carcinoma in situ of the skin revisted: case reports of the superficial type and fibroepithelioma type of this in situ cutaneous neoplasm. Dermatol Online J. 2024. https://doi.org/10.5070/D330163285 .
doi: 10.5070/D330163285
Cohen PR. Superficial basal cell carcinoma of the skin is a cutaneous basal cell carcinoma in situ. SKINmed. In press.
Nicholas AK, Jacques PB. Morphology and ultrastructure of basement membranes. Curr Top Membr. 2005;56:19–42. https://doi.org/10.1016/S1063-5823(05)56002-2 .
doi: 10.1016/S1063-5823(05)56002-2
Tozawa T, Ackerman BA. Basal cell carcinoma with follicular differentiation. Am J Dermatopathol. 1988;10(5):457–466. https://doi.org/10.1097/00000372-198712000-00002 .
Rosai J. Basal cell carcinoma with follicular differentiation. Am J Dermatopathol. 1989;11(5):479–97.
doi: 10.1097/00000372-198910000-00011
pubmed: 2802108
Ackerman AB, de Viragh PA, Chongchitnant N, Reddy V, di Leonardo M. Basal cell carcinoma with follicular differentiation (Chapter 26). In: Ackerman’s histologic diagnosis of neoplastic skin diseases: a method by pattern analysis. Neoplasms with follicular differentiation. Philadelphia: Lea & Febiger; 1993. p. 605–58. https://doi.org/10.1097/00000372-198712000-00002 .
doi: 10.1097/00000372-198712000-00002
Crowson AN. Basal cell carcinoma: biology, morphology and clinical implications. Mod Pathol. 2006;19(Suppl 2):S127–47. https://doi.org/10.1038/modpathol.3800512 .
doi: 10.1038/modpathol.3800512
pubmed: 16446711
Kallioinen M, Autio-Harmainen H, Dammert K, Risteli J, Risteli L. Discontinuity of the basement membrane in fibrosing basocellular carcinomas and basosquamous carcinomas of the skin: an immunohistochemical study with human laminin and type IV collagen antibodies. J Invest Dermatol. 1984;82(3):248–51. https://doi.org/10.1111/1523-1747.ep12260190 .
doi: 10.1111/1523-1747.ep12260190
pubmed: 6366075
Barsky SH, Grossman DA, Bhuta S. Desmoplastic basal cell carcinomas possess unique basement membrane-degrading properties. J Invest Dermatol. 1987;88(3):324–9. https://doi.org/10.1111/1523-1747.ep12466209 .
doi: 10.1111/1523-1747.ep12466209
pubmed: 3029237
Iida J, Wilhelmson KL, Price MA, et al. Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth. J Invest Dermatol. 2004;122(1):167–76. https://doi.org/10.1046/j.0022-202X.2003.22114.x .
doi: 10.1046/j.0022-202X.2003.22114.x
pubmed: 14962105
In situ. Online etymology dictionary. 2022. https://www.etymonline.com/word/in%20situ . Accessed 8 June 2023.
Davis CP. Definition of in situ. TxList. March 29, 2021. https://www.rxlist.com/in_situ/definition.htm . Accessed 8 June 2023.
National Cancer Institute. Carcinoma in situ [NCI’s dictionary of cancer terms]. Dec 4, 2014. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/carcinoma-in-situ . Accessed 8 June 2023.
Villani A, Scalvenzi M, Micali G, et al. An update on the current and emerging pharmacotherapies for basal cell carcinomas. Expert Opin Pharmacother. 2023;24(18):2143–51. https://doi.org/10.1080/14656566.2023.2284351 .
doi: 10.1080/14656566.2023.2284351
pubmed: 37963910