Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns.
CP: Neuroscience
ChAT
D(1) receptor
D(2) receptor
VGAT
Vglut2
cuneiform nucleus
dopamine
locomotion
mesencephalic locomotor region
pedunculopontine nucleus
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
08 May 2024
08 May 2024
Historique:
received:
20
10
2023
revised:
31
03
2024
accepted:
17
04
2024
medline:
10
5
2024
pubmed:
10
5
2024
entrez:
9
5
2024
Statut:
aheadofprint
Résumé
The locomotor role of dopaminergic neurons is traditionally attributed to their ascending projections to the basal ganglia, which project to the mesencephalic locomotor region (MLR). In addition, descending dopaminergic projections to the MLR are present from basal vertebrates to mammals. However, the neurons targeted in the MLR and their behavioral role are unknown in mammals. Here, we identify genetically defined MLR cells that express D
Identifiants
pubmed: 38722743
pii: S2211-1247(24)00515-1
doi: 10.1016/j.celrep.2024.114187
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114187Informations de copyright
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.