Surgical removal of extended-release buprenorphine depot due to adverse reactions.

Buprenorphine Narcotic antagonists Nausea Opioid-related disorders Sublocade® Vomiting

Journal

The American journal of emergency medicine
ISSN: 1532-8171
Titre abrégé: Am J Emerg Med
Pays: United States
ID NLM: 8309942

Informations de publication

Date de publication:
27 Apr 2024
Historique:
received: 16 04 2024
accepted: 25 04 2024
medline: 10 5 2024
pubmed: 10 5 2024
entrez: 9 5 2024
Statut: aheadofprint

Résumé

Extended-release formulations of buprenorphine offer less frequent dosing, provide consistent medication delivery, and improve adherence for treatment of opioid use disorder (OUD). Although buprenorphine is a partial agonist with seemingly less precipitated withdrawal and easier initiation than full opioid agonists used for OUD, its use is not benign and understanding of the different extended-release formulations is necessary. We report a case of a patient that received a long-acting buprenorphine formulation (Sublocade®) administered subcutaneously that presented to the emergency department with tachycardia, hyperglycemia, elevated anion gap, and sustained nausea and vomiting refractory to pharmacotherapy requiring surgical removal of the buprenorphine depot for resolution of nausea and vomiting symptoms.

Identifiants

DOI: 10.1016/j.ajem.2024.04.047 PMID: 38723364
pubmed: 38723364
pii: S0735-6757(24)00206-7
doi: 10.1016/j.ajem.2024.04.047
pii:
doi:

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

127-128

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest None.

Auteurs

Andrew Burton (A)

University of Rochester Medical Center - Thompson Health, 350 Parrish Street, Canandaigua, NY 14424, United States of America. Electronic address: aburton91312@rx.lecom.edu.

Darlene J DeBona (DJ)

Department of Pharmacy, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, United States of America. Electronic address: darlene_debona@urmc.rochester.edu.

Michele Handzel (M)

Department of Pharmacy, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, United States of America. Electronic address: michele_handzel@urmc.rochester.edu.

Sarah Kelly-Pisciotti (S)

Department of Pharmacy, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, United States of America. Electronic address: sarah_kelly@urmc.rochester.edu.

Min Qiao (M)

Department of Medicine, Pulmonary Disease and Critical Care, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, United States of America. Electronic address: min_qiao@urmc.rochester.edu.

Dana Rojek (D)

Critical Care, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, United States of America. Electronic address: Dana_Rojek@urmc.rochester.edu.

Nicole M Acquisto (NM)

Department of Pharmacy, Department of Emergency Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, United States of America. Electronic address: nicole_acquisto@urmc.rochester.edu.

Classifications MeSH