Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.

GWAS epithelial ovarian cancer risk fine mapping functional mechanisms

Journal

American journal of human genetics
ISSN: 1537-6605
Titre abrégé: Am J Hum Genet
Pays: United States
ID NLM: 0370475

Informations de publication

Date de publication:
07 May 2024
Historique:
received: 13 07 2022
revised: 16 04 2024
accepted: 16 04 2024
medline: 10 5 2024
pubmed: 10 5 2024
entrez: 9 5 2024
Statut: aheadofprint

Résumé

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value <5 × 10

Identifiants

DOI: 10.1016/j.ajhg.2024.04.011 PMID: 38723632
pubmed: 38723632
pii: S0002-9297(24)00126-5
doi: 10.1016/j.ajhg.2024.04.011
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Eileen O Dareng (EO)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Simon G Coetzee (SG)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Jonathan P Tyrer (JP)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Pei-Chen Peng (PC)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Will Rosenow (W)

3Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

Stephanie Chen (S)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Applied Genomics, Computation and Translational Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Brian D Davis (BD)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Applied Genomics, Computation and Translational Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Felipe Segato Dezem (FS)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Ji-Heui Seo (JH)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.

Robbin Nameki (R)

Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Alberto L Reyes (AL)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Katja K H Aben (KKH)

Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.

Hoda Anton-Culver (H)

Department of Medicine, Genetic Epidemiology Research Institute, University of California, Irvine, Irvine, CA, USA.

Natalia N Antonenkova (NN)

N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.

Gerasimos Aravantinos (G)

Agii Anargiri' Cancer Hospital, Athens, Greece.

Elisa V Bandera (EV)

Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

Laura E Beane Freeman (LE)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Matthias W Beckmann (MW)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.

Alicia Beeghly-Fadiel (A)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

Javier Benitez (J)

Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.

Marcus Q Bernardini (MQ)

Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada.

Line Bjorge (L)

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.

Amanda Black (A)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Natalia V Bogdanova (NV)

N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Department of Radiation Oncology, Hannover Medical School, Hannover, Germany; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Kelly L Bolton (KL)

Division of Biology and Biomedical Sciences, Washington University, St. Louis, MO, USA.

James D Brenton (JD)

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

Agnieszka Budzilowska (A)

Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Ralf Butzow (R)

Department of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Hui Cai (H)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

Ian Campbell (I)

Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.

Rikki Cannioto (R)

Cancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Kexin Chen (K)

Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Georgia Chenevix-Trench (G)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, VIC, Australia; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia.

Yoke-Eng Chiew (YE)

Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia; Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW, Australia.

Linda S Cook (LS)

Epidemiology, School of Public Health, University of Colorado, Aurora, CO, USA; Community Health Sciences, University of Calgary, Calgary, AB, Canada.

Anna DeFazio (A)

Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia; Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW, Australia; The Daffodil Centre, a joint venture with Cancer Council NSW, The University of Sydney, Sydney, NSW, Australia.

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Jennifer A Doherty (JA)

Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.

Thilo Dörk (T)

Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Andreas du Bois (A)

Department of Gynecology and Gynecological Oncology; HSK, Dr. Horst-Schmidt Klinik, Wiesbaden, Wiesbaden, Germany; Department of Gynecology and Gynecologic Oncology, Evangelische Kliniken Essen-Mitte (KEM), Essen, Germany.

Matthias Dürst (M)

Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.

Diana M Eccles (DM)

Faculty of Medicine, University of Southampton, Southampton, UK.

Gabrielle Ene (G)

Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada.

Peter A Fasching (PA)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.

James M Flanagan (JM)

Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK.

Renée T Fortner (RT)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Florentia Fostira (F)

Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.

Aleksandra Gentry-Maharaj (A)

MRC Clinical Trials Unit, Institute of Clinical Trials & Methodology, University College London, London, UK.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.

Marc T Goodman (MT)

Cancer Prevention and Control Program, Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Jacek Gronwald (J)

Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.

Christopher A Haiman (CA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Niclas Håkansson (N)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Florian Heitz (F)

Department of Gynecology and Gynecological Oncology; HSK, Dr. Horst-Schmidt Klinik, Wiesbaden, Wiesbaden, Germany; Department of Gynecology and Gynecologic Oncology, Evangelische Kliniken Essen-Mitte (KEM), Essen, Germany; Center for Pathology, Evangelische Kliniken Essen-Mitte, Essen, Germany.

Michelle A T Hildebrandt (MAT)

Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Estrid Høgdall (E)

Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

Claus K Høgdall (CK)

Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Ruea-Yea Huang (RY)

Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Allan Jensen (A)

Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Michael E Jones (ME)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Daehee Kang (D)

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Cancer Research Institute, Seoul National University, Seoul, Korea.

Beth Y Karlan (BY)

David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.

Anthony N Karnezis (AN)

Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA.

Linda E Kelemen (LE)

Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.

Catherine J Kennedy (CJ)

Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia; Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW, Australia; The University of Sydney, Sydney, NSW, Australia.

Elza K Khusnutdinova (EK)

Institute of Biochemistry and Genetics of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.

Lambertus A Kiemeney (LA)

Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Susanne K Kjaer (SK)

Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Jolanta Kupryjanczyk (J)

Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Marilyne Labrie (M)

Department of Immunology and Cell Biology, FMSS - Université de Sherbrooke, Sherbrooke, QC, Canada.

Diether Lambrechts (D)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology, VIB, Leuven, Belgium.

Melissa C Larson (MC)

Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA.

Nhu D Le (ND)

Cancer Control Research, BC Cancer, Vancouver, BC, Canada.

Jenny Lester (J)

David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.

Lian Li (L)

Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Jan Lubiński (J)

Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.

Michael Lush (M)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Jeffrey R Marks (JR)

Department of Surgery, Duke University Hospital, Durham, NC, USA.

Keitaro Matsuo (K)

Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan; Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Taymaa May (T)

Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada.

John R McLaughlin (JR)

Public Health Ontario, Samuel Lunenfeld Research Institute, Toronto, ON, Canada.

Iain A McNeish (IA)

Division of Cancer and Ovarian Cancer Action Research Centre, Department Surgery & Cancer, Imperial College London, London, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

Usha Menon (U)

MRC Clinical Trials Unit, Institute of Clinical Trials & Methodology, University College London, London, UK.

Stacey Missmer (S)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Francesmary Modugno (F)

Women's Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Melissa Moffitt (M)

Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Alvaro N Monteiro (AN)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.

Kirsten B Moysich (KB)

Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.

Steven A Narod (SA)

Women's College Research Institute, University of Toronto, Toronto, ON, Canada.

Tu Nguyen-Dumont (T)

Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia.

Kunle Odunsi (K)

University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA.

Håkan Olsson (H)

Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.

N Charlotte Onland-Moret (NC)

Julius Center for Health Sciences and Primary Care, University Utrecht, UMC Utrecht, Utrecht, the Netherlands.

Sue K Park (SK)

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Cancer Research Institute, Seoul National University, Seoul, Korea; Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, South Korea.

Tanja Pejovic (T)

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.

Jennifer B Permuth (JB)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.

Anna Piskorz (A)

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

Darya Prokofyeva (D)

Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.

Marjorie J Riggan (MJ)

Department of Gynecologic Oncology, Duke University Hospital, Durham, NC, USA.

Harvey A Risch (HA)

Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.

Cristina Rodríguez-Antona (C)

Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.

Mary Anne Rossing (MA)

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.

Dale P Sandler (DP)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

V Wendy Setiawan (VW)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Kang Shan (K)

Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.

Honglin Song (H)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Melissa C Southey (MC)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia.

Helen Steed (H)

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada; Section of Gynecologic Oncology Surgery, Alberta Health Services, North Zone, Edmonton, AB, Canada.

Rebecca Sutphen (R)

Epidemiology Center, College of Medicine, University of South Florida, Tampa, FL, USA.

Anthony J Swerdlow (AJ)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.

Soo Hwang Teo (SH)

Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Kathryn L Terry (KL)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gyneoclogy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Pamela J Thompson (PJ)

Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Liv Cecilie Vestrheim Thomsen (LC)

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.

Linda Titus (L)

Muskie School of Public Service, University of Southern Maine, Portland, ME, USA.

Britton Trabert (B)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Ruth Travis (R)

Cancer Epidemiology Unit, University of Oxford, Oxford, UK.

Shelley S Tworoger (SS)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.

Ellen Valen (E)

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.

Els Van Nieuwenhuysen (E)

Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, Leuven Cancer Institute, Leuven, Belgium.

Digna Velez Edwards (DV)

Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Women's Health Research, Vanderbilt University Medical Center, Nashville, TN, USA.

Robert A Vierkant (RA)

Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA.

Penelope M Webb (PM)

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Clarice R Weinberg (CR)

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Rayna Matsuno Weise (RM)

Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Nicolas Wentzensen (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Emily White (E)

Department of Epidemiology, University of Washington, Seattle, WA, USA; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Stacey J Winham (SJ)

Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Yin-Ling Woo (YL)

Department of Obstetrics and Gynaecology, University of Malaya Medical Centre, University of Malaya, Kuala Lumpur, Malaysia.

Anna H Wu (AH)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

Li Yan (L)

Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.

Drakoulis Yannoukakos (D)

Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.

Nur Zeinomar (N)

Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

Argyrios Ziogas (A)

Department of Medicine, Genetic Epidemiology Research Institute, University of California, Irvine, Irvine, CA, USA.

Andrew Berchuck (A)

Department of Gynecologic Oncology, Duke University Hospital, Durham, NC, USA.

Ellen L Goode (EL)

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

David G Huntsman (DG)

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.

Celeste L Pearce (CL)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Susan J Ramus (SJ)

School of Women's and Children's Health, Faculty of Medicine and Health, University of NSW Sydney, Sydney, NSW, Australia; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, NSW, Australia.

Thomas A Sellers (TA)

TAS Consulting, LLC., Portland, OR, USA.

Matthew L Freedman (ML)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.

Kate Lawrenson (K)

Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Joellen M Schildkraut (JM)

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Dennis Hazelett (D)

Samuel Oschin Comprehensive Cancer Institute, The Center for Bioinformatics and Functional Biology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Jasmine T Plummer (JT)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Applied Genomics, Computation and Translational Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Siddhartha Kar (S)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Section of Translational Epidemiology, Division of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Michelle R Jones (MR)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Paul D P Pharoah (PDP)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. Electronic address: pp10001@medschl.cam.ac.uk.

Simon A Gayther (SA)

Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: gayther@uthscsa.edu.

Classifications MeSH