Significance of vitamin D responsiveness on the etiology of vitamin D-related diseases.
Autoimmune diseases
Coimbra protocol
Idiopathic infantile hypercalcemia
Vitamin D
Vitamin D resistance
Vitamin d-linked diseases
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
07 May 2024
07 May 2024
Historique:
received:
16
02
2024
revised:
06
05
2024
accepted:
06
05
2024
medline:
10
5
2024
pubmed:
10
5
2024
entrez:
9
5
2024
Statut:
aheadofprint
Résumé
Vitamin D resistance (VDRES) explains the necessity for higher doses of Vitamin D (VD) than those recommended for treatment success. VD receptor (VDR) signaling blockade, such as that caused by infections and poisons, is one basis for VDRES etiology. Mutations within genes affecting the VD system cause susceptibility to developing low VD responsiveness and autoimmunity. In contrast, VD hypersensitivity (VDHY) occurs if there is extra VD in the body; for example, as a result of an overdose of a VD supplement. Excess 1,25(OH)2D3 is produced in lymphomas and granulomatous diseases. The placenta produces excess 1,25(OH)
Identifiants
pubmed: 38723841
pii: S0039-128X(24)00075-8
doi: 10.1016/j.steroids.2024.109437
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109437Informations de copyright
Copyright © 2024. Published by Elsevier Inc.