Omegasomes control formation, expansion, and closure of autophagosomes.

DFCP1 FYVE domain PI3P omegasome phagophore

Journal

BioEssays : news and reviews in molecular, cellular and developmental biology

ISSN: 1521-1878

Titre abrégé: Bioessays

Pays: United States

ID NLM: 8510851

Informations de publication

Date de publication:
09 May 2024

Historique:

revised: 04 04 2024

received: 15 02 2024

accepted: 05 04 2024

medline: 10 5 2024

pubmed: 10 5 2024

entrez: 9 5 2024

Statut: aheadofprint

Résumé

Autophagy, an essential cellular process for maintaining cellular homeostasis and eliminating harmful cytoplasmic objects, involves the de novo formation of double-membraned autophagosomes that engulf and degrade cellular debris, protein aggregates, damaged organelles, and pathogens. Central to this process is the phagophore, which forms from donor membranes rich in lipids synthesized at various cellular sites, including the endoplasmic reticulum (ER), which has emerged as a primary source. The ER-associated omegasomes, characterized by their distinctive omega-shaped structure and accumulation of phosphatidylinositol 3-phosphate (PI3P), play a pivotal role in autophagosome formation. Omegasomes are thought to serve as platforms for phagophore assembly by recruiting essential proteins such as DFCP1/ZFYVE1 and facilitating lipid transfer to expand the phagophore. Despite the critical importance of phagophore biogenesis, many aspects remain poorly understood, particularly the complete range of proteins involved in omegasome dynamics, and the detailed mechanisms of lipid transfer and membrane contact site formation.

Identifiants

DOI: 10.1002/bies.202400038 PMID: 38724256

pubmed: 38724256

doi: 10.1002/bies.202400038

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

e2400038

Subventions

Organisme : Research Council of Norway

ID : 301369

Organisme : Research Council of Norway

ID : 262652

Organisme : Project Grants from the South-Eastern Norway Regional Health Authority

ID : 2018081

Organisme : Norwegian Cancer Society

ID : 182698

Organisme : Advanced Grant from the European Research Council

ID : 788954

Organisme : South-Eastern Norway Regional Health Authority

ID : 2020038

Organisme : Research Grant from the Research Council of Norway

ID : 315103

Informations de copyright

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