A high-resolution large-area detector for quality assurance in radiotherapy.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 05 2024
09 05 2024
Historique:
received:
07
02
2023
accepted:
30
04
2024
medline:
10
5
2024
pubmed:
10
5
2024
entrez:
9
5
2024
Statut:
epublish
Résumé
Hadron therapy is an advanced radiation modality for treating cancer, which currently uses protons and carbon ions. Hadrons allow for a highly conformal dose distribution to the tumour, minimising the detrimental side-effects due to radiation received by healthy tissues. Treatment with hadrons requires sub-millimetre spatial resolution and high dosimetric accuracy. This paper discusses the design, fabrication and performance tests of a detector based on Gas Electron Multipliers (GEM) coupled to a matrix of thin-film transistors (TFT), with an active area of 60 × 80 mm
Identifiants
pubmed: 38724569
doi: 10.1038/s41598-024-61095-2
pii: 10.1038/s41598-024-61095-2
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10637Informations de copyright
© 2024. The Author(s).
Références
Cho, B. Intensity-modulated radiation therapy: A review with a physics perspective. Radiat. Oncol. J. 36, 1–10 (2018).
doi: 10.3857/roj.2018.00122
Teoh, M., Clark, C. H., Wood, K., Whitaker, S. & Nisbet, A. Volumetric modulated arc therapy: A review of current literature and clinical use in practice. Br. J. Radiol. 84, 967–996 (2011).
doi: 10.1259/bjr/22373346
Matar, F. S. et al. Quality assurance of VMAT on flattened and flattening filter-free accelerators using a high spatial resolution detector. J. Appl. Clin. Med. Phys. 21, 44–52 (2020).
doi: 10.1002/acm2.12864
PTCOG - Patient Statistics https://www.ptcog.site/index.php/patient-statistics-2 (Accessed 09 February 2024).
Majeed, H. & Gupta, V. Adverse effects of radiation therapy. In StatPearls (eds Majeed, H. & Gupta, V.) (StatPearls Publishing, 2023).
Ishikawa, H., Nakai, K., Nonaka, T. & Sakurai, H. Particle therapy in cancer treatment-current and future perspective. Gan To Kagaku Ryoho 46, 1219–1225 (2019).
Glowa, C., Peschke, P., Brons, S., Debus, J. & Karger, C. P. Intrinsic and extrinsic tumor characteristics are of minor relevance for the efficacy of split-dose carbon ion irradiation in three experimental prostate tumors. Radiother. Oncol. 133, 120–124 (2019).
doi: 10.1016/j.radonc.2018.12.017
ICRU Report 78, Prescribing, Recording, and Reporting Proton-Beam Therapy – ICRU. https://www.icru.org/report/prescribing-recording-and-reporting-proton-beam-therapy-icru-report-78/ (2023).
Abreu, C. E. C. V. et al. Stereotactic body radiotherapy in lung cancer: An update *. J. Bras. Pneumol. 41, 376–387 (2015).
doi: 10.1590/S1806-37132015000000034
Matsuo, Y. Stereotactic body radiotherapy for hepatocellular carcinoma: A brief overview. Curr. Oncol. 30, 2493–2500 (2023).
doi: 10.3390/curroncol30020190
Chea, M. et al. Dosimetric study between a single isocenter dynamic conformal arc therapy technique and Gamma Knife radiosurgery for multiple brain metastases treatment: Impact of target volume geometrical characteristics. Radiat. Oncol. 16, 45 (2021).
doi: 10.1186/s13014-021-01766-w
Maia Oliveira, A. et al. Characterization with X-rays of a large-area GEMPix detector with optical readout for QA in hadron therapy. Appl. Sci. 11, 6459 (2021).
doi: 10.3390/app11146459
Amaldi, U. et al. Advanced quality assurance for CNAO. Nuclear Instrum. Methods Phys. Res. Sect. A 617, 248–249 (2010).
doi: 10.1016/j.nima.2009.06.087
Leidner, J., Ciocca, M., Mairani, A., Murtas, F. & Silari, M. A GEMPix-based integrated system for measurements of 3D dose distributions in water for carbon ion scanning beam radiotherapy. Med. Phys. 47, 2516–2525 (2020).
doi: 10.1002/mp.14119
Sauli, F. A new concept for electron amplification in gas detectors. Nuclear Instrum. Methods Phys. Res. Sect. A 386, 532–534 (1997).
doi: 10.1016/S0168-9002(96)01172-2
Oliveira, A. M. et al. A large area GEMPix detector for treatment plan verification in hadron therapy. J. Phys. Conf. Ser. 2374, 012177 (2022).
doi: 10.1088/1742-6596/2374/1/012177
Safai, S., Lin, S. & Pedroni, E. Development of an inorganic scintillating mixture for proton beam verification dosimetry. Phys. Med. Biol. 49, 4637–4655 (2004).
doi: 10.1088/0031-9155/49/19/013
Seravalli, E. et al. 2D dosimetry in a proton beam with a scintillating GEM detector. Phys. Med. Biol. 54, 3755–3771 (2009).
doi: 10.1088/0031-9155/54/12/010
Brunbauer, F. M. Applications of Gas Scintillation Properties in Optically Read Out GEM-Based Detectors (Technical University of Vienna, 2018).
Klyachko, A. V., Moskvin, V., Nichiporov, D. F. & Solberg, K. A. A GEM-based dose imaging detector with optical readout for proton radiotherapy. Nuclear Instrum. Methods Phys. Res. Sect. A 694, 271–279 (2012).
doi: 10.1016/j.nima.2012.08.049
Bencivenni, G. et al. A triple GEM detector with pad readout for high rate charged particle triggering. Nuclear Instrum. Methods Phys. Res. Sect. A 488, 493–502 (2002).
doi: 10.1016/S0168-9002(02)00515-6
Corradi, G., Murtas, F. & Tagnani, D. A novel High-Voltage System for a triple GEM detector. Nuclear Instrum. Methods Phys. Res. Sect. A 572, 96–97 (2007).
doi: 10.1016/j.nima.2006.10.166
Pansky, A. et al. The scintillation of CF4 and its relevance to detection science. Nuclear Instrum. Methods Phys. Res. Sect. A 354, 262–269 (1995).
doi: 10.1016/0168-9002(94)01064-1
Fallavollita, F., Fiorina, D. & Merlin, J. A. Advanced aging study on triple-GEM detectors. J. Phys. Conf. Ser. 1498, 012038 (2020).
doi: 10.1088/1742-6596/1498/1/012038
Sato, A. et al. Amorphous In–Ga–Zn–O coplanar homojunction thin-film transistor. Appl. Phys. Lett. 94, 133502 (2009).
doi: 10.1063/1.3112566
Manoj, N. et al. Low-temperature formation of source–drain contacts in self-aligned amorphous oxide thin-film transistors. J. Inf. Display 16(2), 111–117 (2015).
doi: 10.1080/15980316.2015.1043359
van Breemen, A. J. J. M. et al. A thin and flexible scanner for fingerprints and documents based on metal halide perovskites. Nat. Electron. 4, 818–826 (2021).
doi: 10.1038/s41928-021-00662-1
Brugger, M., Carbonez, P., Pozzi, F., Silari, M. & Vincke, H. New radiation protection calibration facility at CERN. Radiat. Protect. Dosimetry 161, 181–184 (2014).
doi: 10.1093/rpd/nct318
Anders, J. et al. A facility for radiation hardness studies based on a medical cyclotron. J. Inst. 17, P04021 (2022).
Braccini, S. The new Bern PET cyclotron, its research beam line, and the development of an innovative beam monitor detector. AIP Conf. Proc. 1525, 144–150 (2013).
doi: 10.1063/1.4802308
Potkins, D. E. et al. A low-cost beam profiler based on cerium-doped silica fibers. Phys. Procedia 90, 215–222 (2017).
doi: 10.1016/j.phpro.2017.09.061
Sigamani, A. et al. Surface dose measurements and comparison of unflattened and flattened photon beams. J. Med. Phys. 41, 85 (2016).
doi: 10.4103/0971-6203.181648
Donetti, M. et al. Current and future technologies of the CNAO dose delivery system. IEEE Instrum. Meas. Magaz. 24, 61–69 (2021).
doi: 10.1109/MIM.2021.9620025
Friedman, S. N., Fung, G. S. K., Siewerdsen, J. H. & Tsui, B. M. W. A simple approach to measure computed tomography (CT) modulation transfer function (MTF) and noise-power spectrum (NPS) using the American College of Radiology (ACR) accreditation phantom. Med. Phys. 40, 051907 (2013).
doi: 10.1118/1.4800795
Line Pair Patterns - Test Phantoms, QUART X-Ray QA QC Solutions. https://quart.de/en/products/test-phantoms/resolution-patterns/line-pair-patterns (2023).
OCTAVIUS 4D QA Phantom, PTW. https://www.ptwdosimetry.com/en/products/octavius-4d-qa-phantom/ (2024).
Gelinck, G. H. et al. X-ray detector-on-plastic with high sensitivity using low cost, solution-processed organic photodiodes. IEEE Trans. Electron Dev. 63, 197–204 (2016).
doi: 10.1109/TED.2015.2432572
Kim, D.-G. et al. Negative threshold voltage shift in an a-IGZO thin film transistor under X-ray irradiation. RSC Adv. 9, 20865–20870 (2019).
doi: 10.1039/C9RA03053K
Shin, M.-G. et al. Effects of proton beam irradiation on the physical and chemical properties of IGTO thin films with different thicknesses for thin-film transistor applications. Surf. Interfaces 23, 100990 (2021).
doi: 10.1016/j.surfin.2021.100990
More, M., Jain, V. & Gurjar, O. P. Clinical experience of intensity modulated radiotherapy pre-treatment quality assurance for carcinoma head and neck patients with EPID and IMatriXX in rural center. J. Biomed. Phys. Eng. 10, 691–698 (2020).
doi: 10.31661/jbpe.v0i0.2004-1102
Mousli, M. & Cummins, D. EPID dosimetry for IMRT and VMAT PSQA. Physica Medica 52, 173 (2018).
doi: 10.1016/j.ejmp.2018.06.041
Wendling, M. et al. Accurate two-dimensional IMRT verification using a back-projection EPID dosimetry method. Med. Phys. 33, 259–273 (2006).
doi: 10.1118/1.2147744
Steciw, S., Warkentin, B., Rathee, S. & Fallone, B. G. Three-dimensional IMRT verification with a flat-panel EPID. Med. Phys. 32, 600–612 (2005).
doi: 10.1118/1.1843471
Giordanengo, S. et al. The CNAO dose delivery system for modulated scanning ion beam radiotherapy. Med. Phys. 42, 263–275 (2015).
doi: 10.1118/1.4903276
SRIM-2008, Stopping Power and Range of Ions in Matter. https://www.oecd-nea.org/tools/abstract/detail/nea-0919 (2024).
Bolsa-Ferruz, M., Palmans, H., Boersma, D., Stock, M. & Grevillot, L. Monte Carlo computation of 3D distributions of stopping power ratios in light ion beam therapy using GATE-RTion. Med. Phys. 48, 2580–2591 (2021).
doi: 10.1002/mp.14726
Kurz, C., Mairani, A. & Parodi, K. First experimental-based characterization of oxygen ion beam depth dose distributions at the Heidelberg Ion-Beam Therapy Center. Phys. Med. Biol. 57, 5017 (2012).
doi: 10.1088/0031-9155/57/15/5017
Anderson, S. E., Grams, M. P., Tseung, H. W. C., Furutani, K. M. & Beltran, C. J. A linear relationship for the LET-dependence of Gafchromic EBT3 film in spot-scanning proton therapy. Phys. Med. Biol. 64, 055015 (2019).
doi: 10.1088/1361-6560/ab0114