Verbal learning in frontal patients: area 9 is critical for employing semantic strategies.
Area 9
Prefrontal cortex
Semantic clustering
Strategic memory
Verbal learning
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
09 May 2024
09 May 2024
Historique:
received:
24
12
2023
accepted:
02
05
2024
medline:
10
5
2024
pubmed:
10
5
2024
entrez:
9
5
2024
Statut:
aheadofprint
Résumé
Learning is a long-term memory process, influenced by working memory control processes, including recognition of semantic properties of items by which subjects generate a semantic structure of engrams. The aim of the study is to investigate the verbal learning strategies of Parkinson's disease patients. Thirty patients with idiopathic Parkinson's disease and thirty normal control subjects were tested with a multi-trial word list learning, under two conditions: without cue and then with an explicit cue suggesting the categories in the list, respectively. In comparison to healthy control subjects, parkinsonian patients recalled fewer words and achieved a reduced number of categorical clusters; strategical cue did not improve their performance. This suggests, besides a difficulty in identifying the correct learning strategy, a deficit in working memory, which undermines the strategy implementation. We hypothesize that this function pertains to the dorsolateral cognitive circuit of the extrapyramidal system.
Sections du résumé
BACKGROUND
BACKGROUND
Learning is a long-term memory process, influenced by working memory control processes, including recognition of semantic properties of items by which subjects generate a semantic structure of engrams.
AIM
OBJECTIVE
The aim of the study is to investigate the verbal learning strategies of Parkinson's disease patients.
METHODS
METHODS
Thirty patients with idiopathic Parkinson's disease and thirty normal control subjects were tested with a multi-trial word list learning, under two conditions: without cue and then with an explicit cue suggesting the categories in the list, respectively.
RESULTS AND CONCLUSIONS
CONCLUSIONS
In comparison to healthy control subjects, parkinsonian patients recalled fewer words and achieved a reduced number of categorical clusters; strategical cue did not improve their performance. This suggests, besides a difficulty in identifying the correct learning strategy, a deficit in working memory, which undermines the strategy implementation. We hypothesize that this function pertains to the dorsolateral cognitive circuit of the extrapyramidal system.
Identifiants
pubmed: 38724753
doi: 10.1007/s10072-024-07569-7
pii: 10.1007/s10072-024-07569-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
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