Transcriptomic Signature and Pro-Osteoclastic Secreted Factors of Abnormal Bone-Marrow Stromal Cells in Fibrous Dysplasia.

Humans Animals Mesenchymal Stem Cells / metabolism Transcriptome / genetics Mice Fibrous Dysplasia of Bone / genetics Male Female Cytokines / metabolism GTP-Binding Protein alpha Subunits, Gs / metabolism Adult Middle Aged
bone-marrow stromal cell cytokines fibrous dysplasia osteoclast osteoprogenitor skeletal stem cell skeleton

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
30 Apr 2024
Historique:
received: 14 03 2024
revised: 24 04 2024
accepted: 26 04 2024
medline: 10 5 2024
pubmed: 10 5 2024
entrez: 10 5 2024
Statut: epublish

Résumé

Fibrous dysplasia (FD) is a mosaic skeletal disorder caused by somatic activating variants of

Identifiants

DOI: 10.3390/cells13090774 PMID: 38727310
pubmed: 38727310
pii: cells13090774
doi: 10.3390/cells13090774
pii:
doi:

Substances chimiques

Cytokines 0
GTP-Binding Protein alpha Subunits, Gs EC 3.6.5.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : ZIA DE000649 25
Pays : United States

Auteurs

Zachary Michel (Z)

Metabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
ORCID: 0000-0001-5220-4046

Layne N Raborn (LN)

Skeletal Diseases and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 207, Bethesda, MD 20892, USA.
ORCID: 0000-0001-6925-2677

Tiahna Spencer (T)

Skeletal Diseases and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 207, Bethesda, MD 20892, USA.

Kristen S Pan (KS)

Metabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

Daniel Martin (D)

Genomics and Computational Biology Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

Kelly L Roszko (KL)

Skeletal Diseases and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 207, Bethesda, MD 20892, USA.

Yan Wang (Y)

Mass Spectrometry Facility, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
ORCID: 0000-0003-1187-9527

Pamela G Robey (PG)

Skeletal Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
ORCID: 0000-0002-5316-5576

Michael T Collins (MT)

Skeletal Diseases and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 207, Bethesda, MD 20892, USA.

Alison M Boyce (AM)

Metabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

Luis Fernandez de Castro (LF)

Skeletal Diseases and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 207, Bethesda, MD 20892, USA.
ORCID: 0000-0003-3194-9780

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Eucaryotes › Animaux › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Dysplasies osseuses › Dysplasie fibreuse des os › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Sous-unités alpha Gs des protéines G › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Transcriptomic Signature and Pro-Osteoclastic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Transcriptomic Signature and Pro-Osteoclastic...