Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity.

Humans Single-Cell Analysis Immunotherapy, Adoptive / methods Receptors, Chimeric Antigen / immunology Autoimmunity / immunology Neuromyelitis Optica / immunology Female Male Adult Middle Aged Central Nervous System / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
10 May 2024
Historique:
medline: 10 5 2024
pubmed: 10 5 2024
entrez: 10 5 2024
Statut: ppublish

Résumé

Chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of neurological autoimmune diseases is promising, but CAR T cell kinetics and immune alterations after treatment are poorly understood. Here, we performed single-cell multi-omics sequencing of paired cerebrospinal fluid (CSF) and blood samples from patients with neuromyelitis optica spectrum disorder (NMOSD) treated with anti-B cell maturation antigen (BCMA) CAR T cells. Proliferating cytotoxic-like CD8

Identifiants

DOI: 10.1126/sciimmunol.adj9730 PMID: 38728414
pubmed: 38728414
doi: 10.1126/sciimmunol.adj9730
doi:

Substances chimiques

Receptors, Chimeric Antigen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj9730

Auteurs

Chuan Qin (C)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.
ORCID: 0000-0001-5162-3150

Min Zhang (M)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.
ORCID: 0000-0003-3752-9808

Da-Peng Mou (DP)

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing, China.

Luo-Qi Zhou (LQ)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.

Ming-Hao Dong (MH)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.
ORCID: 0000-0003-2687-0269

Liang Huang (L)

Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
ORCID: 0000-0002-8370-3232

Wen Wang (W)

Nanjing IASO Biotechnology Co. Ltd., Nanjing, China.
ORCID: 0000-0003-3215-3020

Song-Bai Cai (SB)

Nanjing IASO Biotechnology Co. Ltd., Nanjing, China.
ORCID: 0009-0009-2457-2058

Yun-Fan You (YF)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.
ORCID: 0000-0003-3558-8257

Ke Shang (K)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.

Jun Xiao (J)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.

Di Wang (D)

Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Chun-Rui Li (CR)

Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
ORCID: 0000-0001-5134-7133

Yi Hao (Y)

Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Michael Heming (M)

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
ORCID: 0000-0002-9568-2790

Long-Jun Wu (LJ)

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
ORCID: 0000-0001-8019-3380

Gerd Meyer Zu Hörste (GMZ)

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
ORCID: 0000-0002-4341-4719

Chen Dong (C)

Shanghai Immune Therapy Institute, Shanghai Jiaotong University School of Medicine-affiliated Renji Hospital, Shanghai, China.
ORCID: 0000-0002-0084-9130

Bi-Tao Bu (BT)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.
ORCID: 0000-0002-9106-0361

Dai-Shi Tian (DS)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.
ORCID: 0000-0002-7627-0811

Wei Wang (W)

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.
ORCID: 0000-0002-9176-5150

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Single-cell analysis of anti-BCMA CAR T cell...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Single-cell analysis of anti-BCMA CAR T cell...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › Single-cell analysis of anti-BCMA CAR T cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs chimériques pour l'antigène › Single-cell analysis of anti-BCMA CAR T cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Single-cell analysis of anti-BCMA CAR T cell...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Neuromyélite optique › Single-cell analysis of anti-BCMA CAR T cell...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Single-cell analysis of anti-BCMA CAR T cell...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Single-cell analysis of anti-BCMA CAR T cell...
questionsmedicales.fr › Système nerveux › Système nerveux central › Single-cell analysis of anti-BCMA CAR T cell...