A single subcutaneous dose of eprinomectin (Eprecis
Animals
Goats
Ivermectin
/ analogs & derivatives
Goat Diseases
/ drug therapy
Female
Nematode Infections
/ veterinary
Feces
/ parasitology
Lactation
/ drug effects
Parasite Egg Count
/ veterinary
Injections, Subcutaneous
/ veterinary
Anthelmintics
/ administration & dosage
Nematoda
/ drug effects
Gastrointestinal Diseases
/ veterinary
Lung
/ parasitology
Dictyocaulus filaria
Haemonchus contortus
Teladorsagia circumcincta
Trichostrongylus colubriformis
Controlled trial
Eprinomectin
Gastrointestinal nematodes
Lactating goats
Lungworms
Treatment
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
10 May 2024
10 May 2024
Historique:
received:
07
11
2023
accepted:
24
04
2024
medline:
11
5
2024
pubmed:
11
5
2024
entrez:
10
5
2024
Statut:
epublish
Résumé
The health and productivity of dairy goats continue to be impacted by gastrointestinal nematodes (GIN) and lungworms (LW). Eprinomectin (EPN) is frequently selected for treatment because it is generally effective and does not require a milk withdrawal period. However, some factors, such as lactation, can have an impact on EPN pharmacokinetics and potentially its efficacy. To evaluate whether this can alter the efficacy of Eprecis This study was a blinded, randomized, controlled trial performed according to the VICH guidelines. Eighteen (18) worm-free lactating goats were included and experimentally challenged on day 28 with a mixed culture of infective gastrointestinal and lung nematode larvae (Haemonchus contortus, Trichostrongylus colubriformis, Teladorsagia circumcincta, Dictyocaulus filaria). At D-1, fecal samples were collected to confirm patent infection in all animals. On D0, the goats were randomly allocated into two groups of nine goats; group 1 was treated with Eprecis The treatment was well tolerated. After treatment, the arithmetic mean FEC decreased in the treated group and remained < 5 EPG until the end of the study, while the arithmetic mean FEC in the control group remained > 849.0 EPG. At D14, goats in the treated group had very limited or zero total worm counts, whereas all animals from the control group had a high worm burden. The measured efficacy was 100.0% against H. contortus and T. colubriformis, 99.9% against T. circumcincta and 98.0% against D. filaria. Eprinomectin (Eprecis
Sections du résumé
BACKGROUND
BACKGROUND
The health and productivity of dairy goats continue to be impacted by gastrointestinal nematodes (GIN) and lungworms (LW). Eprinomectin (EPN) is frequently selected for treatment because it is generally effective and does not require a milk withdrawal period. However, some factors, such as lactation, can have an impact on EPN pharmacokinetics and potentially its efficacy. To evaluate whether this can alter the efficacy of Eprecis
METHODS
METHODS
This study was a blinded, randomized, controlled trial performed according to the VICH guidelines. Eighteen (18) worm-free lactating goats were included and experimentally challenged on day 28 with a mixed culture of infective gastrointestinal and lung nematode larvae (Haemonchus contortus, Trichostrongylus colubriformis, Teladorsagia circumcincta, Dictyocaulus filaria). At D-1, fecal samples were collected to confirm patent infection in all animals. On D0, the goats were randomly allocated into two groups of nine goats; group 1 was treated with Eprecis
RESULTS
RESULTS
The treatment was well tolerated. After treatment, the arithmetic mean FEC decreased in the treated group and remained < 5 EPG until the end of the study, while the arithmetic mean FEC in the control group remained > 849.0 EPG. At D14, goats in the treated group had very limited or zero total worm counts, whereas all animals from the control group had a high worm burden. The measured efficacy was 100.0% against H. contortus and T. colubriformis, 99.9% against T. circumcincta and 98.0% against D. filaria.
CONCLUSIONS
CONCLUSIONS
Eprinomectin (Eprecis
Identifiants
pubmed: 38730429
doi: 10.1186/s13071-024-06301-w
pii: 10.1186/s13071-024-06301-w
doi:
Substances chimiques
eprinomectin
75KP30FD8O
Ivermectin
70288-86-7
Anthelmintics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
211Informations de copyright
© 2024. The Author(s).
Références
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