Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via Ca
T-type calcium channels
acute post-surgical pain
peripheral pain
venom peptides
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Apr 2024
26 Apr 2024
Historique:
received:
19
03
2024
revised:
23
04
2024
accepted:
24
04
2024
medline:
11
5
2024
pubmed:
11
5
2024
entrez:
11
5
2024
Statut:
epublish
Résumé
Venom peptides have evolved to target a wide range of membrane proteins through diverse mechanisms of action and structures, providing promising therapeutic leads for diseases, including pain, epilepsy, and cancer, as well as unique probes of ion channel structure-function. In this work, a high-throughput FLIPR window current screening assay on T-type Ca
Identifiants
pubmed: 38731963
pii: ijms25094745
doi: 10.3390/ijms25094745
pii:
doi:
Substances chimiques
Calcium Channels, T-Type
0
Scorpion Venoms
0
Calcium
SY7Q814VUP
Cacna1h protein, mouse
0
Calcium Channel Blockers
0
CACNA1H protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Natural Science Foundation of the Jiangsu Higher Education Institutions of China
ID : 21KJB350023
Organisme : Senior Talent Foundation of Jiangsu University
ID : 20JDG075
Organisme : Innovative and Entrepreneurial Program of Jiangsu Province
ID : JSSCBS20210960
Organisme : National Health and Medical Research Council
ID : APP1072113
Organisme : Australian Research Council Future Fellowship
ID : FT190100482