A Structural In Silico Analysis of the Immunogenicity of L-Asparaginase from
Asparaginase
/ chemistry
Penicillium
/ immunology
Computer Simulation
Amino Acid Sequence
Fungal Proteins
/ chemistry
Epitopes, B-Lymphocyte
/ immunology
Epitopes, T-Lymphocyte
/ immunology
Humans
Aspergillus
/ immunology
Escherichia coli
/ genetics
Dickeya chrysanthemi
/ enzymology
Models, Molecular
ALL
L-asparaginase
Penicillium cerradense
immunogenicity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Apr 2024
27 Apr 2024
Historique:
received:
26
03
2024
revised:
23
04
2024
accepted:
24
04
2024
medline:
11
5
2024
pubmed:
11
5
2024
entrez:
11
5
2024
Statut:
epublish
Résumé
L-asparaginase is an essential drug used to treat acute lymphoid leukemia (ALL), a cancer of high prevalence in children. Several adverse reactions associated with L-asparaginase have been observed, mainly caused by immunogenicity and allergenicity. Some strategies have been adopted, such as searching for new microorganisms that produce the enzyme and applying protein engineering. Therefore, this work aimed to elucidate the molecular structure and predict the immunogenic profile of L-asparaginase from
Identifiants
pubmed: 38732010
pii: ijms25094788
doi: 10.3390/ijms25094788
pii:
doi:
Substances chimiques
Asparaginase
EC 3.5.1.1
Fungal Proteins
0
Epitopes, B-Lymphocyte
0
Epitopes, T-Lymphocyte
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Foundation for Research Support of the Federal District
ID : 0193.001797/2017
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 193.0000919-2020/07
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : 001