Unveiling the Genomic Landscape of Intraductal Carcinoma of the Prostate Using Spatial Gene Expression Analysis.
hypoxic markers
immune cells
intraductal carcinoma of the prostate (IDCP)
spatial gene expression analysis
tumor microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Apr 2024
28 Apr 2024
Historique:
received:
14
03
2024
revised:
11
04
2024
accepted:
19
04
2024
medline:
11
5
2024
pubmed:
11
5
2024
entrez:
11
5
2024
Statut:
epublish
Résumé
Intraductal carcinoma of the prostate (IDCP) has recently attracted increasing interest owing to its unfavorable prognoses. To effectively identify the IDCP-specific gene expression profile, we took a novel approach of characterizing a typical IDCP case using spatial gene expression analysis. A formalin-fixed, paraffin-embedded sample was subjected to Visium CytAssist Spatial Gene Expression analysis. IDCP within invasive prostate cancer sites was recognized as a distinct cluster separate from other invasive cancer clusters. Highly expressed genes defining the IDCP cluster, such as
Identifiants
pubmed: 38732035
pii: ijms25094818
doi: 10.3390/ijms25094818
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
CCR5 protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Receptors, CCR5
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 22K09449
Organisme : Takeda Science Foundation
ID : Medical Research Grants
Organisme : Japanese Foundation for Prostate Research
ID : N/A
Organisme : Japanese Urological Association
ID : Young Research Grant
Organisme : Takahashi Industrial and Economic Research Foundation
ID : N/A