Vitamin D Attenuates Fibrotic Properties of Fibrous Dysplasia-Derived Cells for the Transit towards Osteocytic Phenotype.

Humans Cell Proliferation / drug effects Fibrous Dysplasia of Bone / metabolism Phenotype Vitamin D / pharmacology Fibrosis Osteoblasts / drug effects Cell Movement / drug effects Cell Differentiation / drug effects Calcitriol / pharmacology Cells, Cultured
bone disease fibrosis fibrous dysplasia mineralization vitamin D

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
01 May 2024
Historique:
received: 05 04 2024
revised: 29 04 2024
accepted: 30 04 2024
medline: 11 5 2024
pubmed: 11 5 2024
entrez: 11 5 2024
Statut: epublish

Résumé

Fibrous dysplasia (FD) poses a therapeutic challenge due to the dysregulated extracellular matrix (ECM) accumulation within affected bone tissues. In this study, we investigate the therapeutic potential of 1,25-dihydroxyvitamin D3 (1,25(OH)

Identifiants

DOI: 10.3390/ijms25094954 PMID: 38732172
pubmed: 38732172
pii: ijms25094954
doi: 10.3390/ijms25094954
pii:
doi:

Substances chimiques

Vitamin D 1406-16-2
Calcitriol FXC9231JVH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Ministry of Health and Welfare
ID : HR22C1363

Auteurs

Ha-Young Kim (HY)

Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.
Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
ORCID: 0000-0002-7613-5249

Jung-Hee Shim (JH)

Department of Research Administration Team, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.

Baek-Kyu Kim (BK)

Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.

Chan-Yeong Heo (CY)

Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.
Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
ORCID: 0000-0001-9003-7365

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Dysplasies osseuses › Dysplasie fibreuse des os › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholécalciférol › Hydroxycholécalciférols › Dihydroxycholécalciférols › Calcitriol › Vitamin D Attenuates Fibrotic Properties of...
questionsmedicales.fr › Cellules › Cellules cultivées › Vitamin D Attenuates Fibrotic Properties of...