Colloidal and Biological Characterization of Dual Drug-Loaded Smart Micellar Systems.
drug delivery system
pH-sensitive polymeric micelles
paclitaxel
poly(2-vinyl pyridine)-b-poly(ethylene oxide)
ursolic acid
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
24 Apr 2024
24 Apr 2024
Historique:
received:
29
03
2024
revised:
20
04
2024
accepted:
23
04
2024
medline:
11
5
2024
pubmed:
11
5
2024
entrez:
11
5
2024
Statut:
epublish
Résumé
Smart polymeric micelles (PMs) are of great interest in drug delivery owing to their low critical micellar concentration and sizes. In the present study, two different pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) copolymer samples were used for the encapsulation of paclitaxel (PTX), ursolic acid (UA), and dual loading of PTX and UA. Based on the molecular features of copolymers, spherical PMs with sizes of around 35 nm and 140 nm were obtained by dialysis for P2VP
Identifiants
pubmed: 38732658
pii: polym16091189
doi: 10.3390/polym16091189
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii
ID : PN-III-P1-1.1-PD-2021-0346