Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium.

Activation mode Molecular evolution TRPM2 channel

Journal

Science bulletin
ISSN: 2095-9281
Titre abrégé: Sci Bull (Beijing)
Pays: Netherlands
ID NLM: 101655530

Informations de publication

Date de publication:
26 Apr 2024
Historique:
received: 20 09 2023
revised: 07 02 2024
accepted: 19 04 2024
medline: 12 5 2024
pubmed: 12 5 2024
entrez: 11 5 2024
Statut: aheadofprint

Résumé

Ion channel activation upon ligand gating triggers a myriad of biological events and, therefore, evolution of ligand gating mechanism is of fundamental importance. TRPM2, a typical ancient ion channel, is activated by adenosine diphosphate ribose (ADPR) and calcium and its activation has evolved from a simple mode in invertebrates to a more complex one in vertebrates, but the evolutionary process is still unknown. Molecular evolutionary analysis of TRPM2s from more than 280 different animal species has revealed that, the C-terminal NUDT9-H domain has evolved from an enzyme to a ligand binding site for activation, while the N-terminal MHR domain maintains a conserved ligand binding site. Calcium gating pattern has also evolved, from one Ca

Identifiants

DOI: 10.1016/j.scib.2024.04.052 PMID: 38734586
pubmed: 38734586
pii: S2095-9273(24)00301-3
doi: 10.1016/j.scib.2024.04.052
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Science China Press. Published by Elsevier B.V. All rights reserved.

Auteurs

Cheng Ma (C)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Protein Facility, Core Facilities, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China.

Yanping Luo (Y)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Congyi Zhang (C)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Cheng Cheng (C)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Ning Hua (N)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Xiaocao Liu (X)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Jianan Wu (J)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Luying Qin (L)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Peilin Yu (P)

Department of Toxicology, and Department of Medical Oncology of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Jianhong Luo (J)

Department of Neurobiology, Affiliated Mental Health Center, College of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.

Fan Yang (F)

Department of Biophysics, and Kidney Disease Center of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Lin-Hua Jiang (LH)

Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, and Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang 453004, China; Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453004, China.

Guojie Zhang (G)

Evolutionary & Organismal Biology Research Center, School of Medicine, Zhejiang University, Hangzhou 310058, China.

Wei Yang (W)

Department of Biophysics and Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; GuiZhou University Medical College, Guiyang 550025, China. Electronic address: yangwei@zju.edu.cn.

Classifications MeSH