Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.


Journal

Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092

Informations de publication

Date de publication:
11 May 2024
Historique:
received: 14 11 2023
accepted: 30 04 2024
revised: 29 04 2024
medline: 12 5 2024
pubmed: 12 5 2024
entrez: 11 5 2024
Statut: epublish

Résumé

We created valrubicin-loaded immunoliposomes (Val-ILs) using the antitumor prodrug valrubicin, a hydrophobic analog of daunorubicin. Being lipophilic, valrubicin readily incorporated Val-lLs that were loaded with specific antibodies. Val-ILs injected intravenously rapidly reached the bone marrow and spleen, indicating their potential to effectively target cancer cells in these areas. Following the transplantation of human pediatric B-cell acute lymphoblastic leukemia (B-ALL), T-cell acute lymphoblastic leukemia (T-ALL), or acute myeloid leukemia (AML) in immunodeficient NSG mice, we generated patient-derived xenograft (PDX) models, which were treated with Val-ILs loaded with antibodies to target CD19, CD7 or CD33. Only a small amount of valrubicin incorporated into Val-ILs was needed to induce leukemia cell death in vivo, suggesting that this approach could be used to efficiently treat acute leukemia cells. We also demonstrated that Val-ILs could reduce the risk of contamination of CD34

Identifiants

pubmed: 38734740
doi: 10.1038/s41419-024-06715-5
pii: 10.1038/s41419-024-06715-5
doi:

Substances chimiques

Liposomes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

328

Informations de copyright

© 2024. The Author(s).

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Auteurs

Aleksandra Georgievski (A)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France.
LipSTIC Labex, Dijon, France.

Pierre-Simon Bellaye (PS)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France.
Plateforme d'imagerie et de radiothérapie précliniques, Centre Georges François Leclerc-Unicancer, Dijon, France.

Benjamin Tournier (B)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France.
Service de Pathologie, Plateforme de génétique somatique des cancers de Bourgogne, CHU Dijon-Bourgogne, Dijon, France.

Hélène Choubley (H)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France.
LipSTIC Labex, Dijon, France.
Plateforme DiviOmics, UMS58 Inserm BioSanD, Université de Bourgogne, Dijon, France.

Jean-Paul Pais de Barros (JP)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France.
LipSTIC Labex, Dijon, France.
Plateforme DiviOmics, UMS58 Inserm BioSanD, Université de Bourgogne, Dijon, France.

Michaële Herbst (M)

Laboratoire Interdisciplinaire Carnot de Bourgogne, UMR6303 CNRS/Université de Bourgogne, Dijon, France.

Arnaud Béduneau (A)

LipSTIC Labex, Dijon, France.
Université de Franche-Comté, EFS, Inserm, UMR1098 RIGHT, Besançon, France.

Patrick Callier (P)

Laboratoire de Génétique Chromosomique et Moléculaire, CHU Dijon-Bourgogne, Dijon, France.

Bertrand Collin (B)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France.
Plateforme d'imagerie et de radiothérapie précliniques, Centre Georges François Leclerc-Unicancer, Dijon, France.

Frédérique Végran (F)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France.
LipSTIC Labex, Dijon, France.
Centre Georges François Leclerc-Unicancer, Dijon, France.

Paola Ballerini (P)

Laboratoire d'Hématologie, Assistance Publique-Hôpitaux de Paris, Hôpital Armand Trousseau, Paris, France.

Carmen Garrido (C)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France.
LipSTIC Labex, Dijon, France.
Centre Georges François Leclerc-Unicancer, Dijon, France.
Label of excellence from la Ligue Nationale contre le Cancer, Paris, France.

Ronan Quéré (R)

Center for Translational and Molecular Medicine, UMR1231 Inserm/Université de Bourgogne, Dijon, France. ronan.quere@inserm.fr.
LipSTIC Labex, Dijon, France. ronan.quere@inserm.fr.

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