From genetic mosaicism to tumorigenesis through indirect genetic effects.

cellular stochasticity cell‐cell communications genetic mosaicism indirect genetic effects phenotypic instability tissue disruption tissue homeostasis

Journal

BioEssays : news and reviews in molecular, cellular and developmental biology

ISSN: 1521-1878

Titre abrégé: Bioessays

Pays: United States

ID NLM: 8510851

Informations de publication

Date de publication:
12 May 2024

Historique:

revised: 19 04 2024

received: 13 12 2023

accepted: 22 04 2024

medline: 13 5 2024

pubmed: 13 5 2024

entrez: 13 5 2024

Statut: aheadofprint

Résumé

Genetic mosaicism has long been linked to aging, and several hypotheses have been proposed to explain the potential connections between mosaicism and susceptibility to cancer. It has been proposed that mosaicism may disrupt tissue homeostasis by affecting intercellular communications and releasing microenvironmental constraints within tissues. The underlying mechanisms driving these tissue-level influences remain unidentified, however. Here, we present an evolutionary perspective on the interplay between mosaicism and cancer, suggesting that the tissue-level impacts of genetic mosaicism can be attributed to Indirect Genetic Effects (IGEs). IGEs can increase the level of cellular stochasticity and phenotypic instability among adjacent cells, thereby elevating the risk of cancer development within the tissue. Moreover, as cells experience phenotypic changes in response to challenging microenvironmental conditions, these changes can initiate a cascade of nongenetic alterations, referred to as Indirect non-Genetic Effects (InGEs), which in turn catalyze IGEs among surrounding cells. We argue that incorporating both InGEs and IGEs into our understanding of the process of oncogenic transformation could trigger a major paradigm shift in cancer research with far-reaching implications for practical applications.

Identifiants

DOI: 10.1002/bies.202300238 PMID: 38736323

pubmed: 38736323

doi: 10.1002/bies.202300238

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

e2300238

Subventions

Organisme : CNRS

Organisme : Agence Nationale de la Recherche

ID : EVOSEXCAN

Organisme : Agence Nationale de la Recherche

ID : ANR-23-CE13-0007

Organisme : The Hoffmann family

Informations de copyright

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