Nitrous Oxide-induced Myeloneuropathy Due to Recreational Abuse.
Humans
Nitrous Oxide
/ adverse effects
Male
Adult
Vitamin B 12
/ administration & dosage
Female
Israel
/ epidemiology
Magnetic Resonance Imaging
/ methods
Spinal Cord Diseases
/ chemically induced
Paresthesia
/ chemically induced
Middle Aged
Recreational Drug Use
Gait Ataxia
/ chemically induced
Young Adult
Substance-Related Disorders
/ complications
Vitamin B 12 Deficiency
/ chemically induced
Journal
The Israel Medical Association journal : IMAJ
ISSN: 1565-1088
Titre abrégé: Isr Med Assoc J
Pays: Israel
ID NLM: 100930740
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
medline:
13
5
2024
pubmed:
13
5
2024
entrez:
13
5
2024
Statut:
ppublish
Résumé
The recreational use of nitrous oxide (N2O) has increased in recent years with a noticeable surge in the incidence of nitrous oxide-related myeloneuropathy. To raise awareness of increasing myeloneuropathy due to recreational nitrous oxide misuse in Israel. We conducted a case series documenting the clinical and investigative features of eight patients presenting with nitrous oxide-induced myeloneuropathy who were admitted to our departments. Paresthesia was the chief complaint in all patients, with sensory gait ataxia being a common feature, which was often accompanied by Romberg's sign and mild lower limb weakness. Vitamin B12 levels were below the normal range in seven patients, accompanied by elevated homocysteine and methylmalonic acid levels. Magnetic resonance imaging scans revealed hyperintense signals in the dorsal columns of the cervical spine. All patients improved following vitamin B12 injections. Enhancing awareness, prompting the use of appropriate investigations, and advocating for timely treatment are needed to overcome the risks associated with nitrous oxide misuse.
Sections du résumé
BACKGROUND
BACKGROUND
The recreational use of nitrous oxide (N2O) has increased in recent years with a noticeable surge in the incidence of nitrous oxide-related myeloneuropathy.
OBJECTIVES
OBJECTIVE
To raise awareness of increasing myeloneuropathy due to recreational nitrous oxide misuse in Israel.
METHODS
METHODS
We conducted a case series documenting the clinical and investigative features of eight patients presenting with nitrous oxide-induced myeloneuropathy who were admitted to our departments.
RESULTS
RESULTS
Paresthesia was the chief complaint in all patients, with sensory gait ataxia being a common feature, which was often accompanied by Romberg's sign and mild lower limb weakness. Vitamin B12 levels were below the normal range in seven patients, accompanied by elevated homocysteine and methylmalonic acid levels. Magnetic resonance imaging scans revealed hyperintense signals in the dorsal columns of the cervical spine. All patients improved following vitamin B12 injections.
CONCLUSIONS
CONCLUSIONS
Enhancing awareness, prompting the use of appropriate investigations, and advocating for timely treatment are needed to overcome the risks associated with nitrous oxide misuse.
Substances chimiques
Nitrous Oxide
K50XQU1029
Vitamin B 12
P6YC3EG204
Types de publication
Journal Article
Case Reports
Langues
eng
Sous-ensembles de citation
IM