Extracellular vesicles as human therapeutics: A scoping review of the literature.
clinical trials
exosomes
extracellular vesicles
therapeutics
Journal
Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
revised:
03
03
2024
received:
04
09
2023
accepted:
27
03
2024
medline:
13
5
2024
pubmed:
13
5
2024
entrez:
13
5
2024
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) are released by all cells and contribute to cell-to-cell communication. The capacity of EVs to target specific cells and to efficiently deliver a composite profile of functional molecules have led researchers around the world to hypothesize their potential as therapeutics. While studies of EV treatment in animal models are numerous, their actual clinical benefit in humans has more slowly started to be tested. In this scoping review, we searched PubMed and other databases up to 31 December 2023 and, starting from 13,567 records, we selected 40 pertinent published studies testing EVs as therapeutics in humans. The analysis of those 40 studies shows that they are all small pilot trials with a large heterogeneity in terms of administration route and target disease. Moreover, the absence of a placebo control in most of the studies, the predominant local application of EV formulations and the inconsistent administration dose metric still impede comparison across studies and firm conclusions about EV safety and efficacy. On the other hand, the recording of some promising outcomes strongly calls out for well-designed larger studies to test EVs as an alternative approach to treat human diseases with no or few therapeutic options.
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12433Informations de copyright
© 2024 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.
Références
Ahn, H., Jung, W. J., Lee, S. Y., & Lee, K. H. (2023). Recovery from Bell's palsy after treatment using uncultured umbilical cord‐derived mesenchymal stem cells: A case report. World Journal of Clinical Cases, 11(12), 2817–2824. https://doi.org/10.12998/wjcc.v11.i12.2817
Al‐Masawa, M. E., Alshawsh, M. A., Ng, C. Y., Ng, A. M. H., Foo, J. B., Vijakumaran, U., Subramaniam, R., Ghani, N. A. A., Witwer, K. W., & Law, J. X. (2022). Efficacy and safety of small extracellular vesicle interventions in wound healing and skin regeneration: A systematic review and meta‐analysis of animal studies. Theranostics, 12(15), 6455–6508. https://doi.org/10.7150/thno.7343
Assar, S., Mohammadzadeh, D., Norooznezhad, A. H., Payandeh, M., Hassaninia, D., Pournazari, M., Soufivand, P., Yarani, R., & Mansouri, K. (2023). Improvement in the clinical manifestations of interstitial lung disease following treatment with placental mesenchymal stromal cell extracellular vesicles in a patient with systemic sclerosis: A case report. Respiratory Medicine Case Reports, 46, 101923. https://doi.org/10.1016/j.rmcr.2023.101923
Bai, L., Shao, H., Wang, H., Zhang, Z., Su, C., Dong, L., Yu, B., Chen, X., Li, X., & Zhang, X. (2017). Effects of mesenchymal stem cell‐derived exosomes on experimental autoimmune uveitis. Scientific Reports, 7(1), 4323. https://doi.org/10.1038/s41598‐017‐04559‐y
Bellio, M. A., Bennett, C., Arango, A., Khan, A., Xu, X., Barrera, C., Friedewald, V., & Mitrani, M. I. (2021). Proof‐of‐concept trial of an amniotic fluid‐derived extracellular vesicle biologic for treating high risk patients with mild‐to‐moderate acute COVID‐19 infection. Biomaterials and Biosystems, 4, 100031. https://doi.org/10.1016/j.bbiosy.2021.100031
Berardesca, E., Farage, M., & Maibach, H. (2013). Sensitive skin: An overview. International Journal of Cosmetic Science, 35(1), 2–8. https://doi.org/10.1111/j.1468‐2494.2012.00754.x
Besse, B., Charrier, M., Lapierre, V., Dansin, E., Lantz, O., Planchard, D., Le Chevalier, T., Livartoski, A., Barlesi, F., Laplanche, A., Ploix, S., Vimond, N., Peguillet, I., Théry, C., Lacroix, L., Zoernig, I., Dhodapkar, K., Dhodapkar, M., Viaud, S., … Chaput, N. (2015). Dendritic cell‐derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC. Oncoimmunology, 5(4), e1071008. https://doi.org/10.1080/2162402X.2015.1071008
Buzas, E. I. (2023). The roles of extracellular vesicles in the immune system. Nature Reviews. Immunology, 23(4), 236–250. https://doi.org/10.1038/s41577‐022‐00763‐8
Ceriello, A., Catrinoiu, D., Chandramouli, C., Cosentino, F., Dombrowsky, A. C., Itzhak, B., Lalic, N. M., Prattichizzo, F., Schnell, O., Seferović, P. M., Valensi, P., Standl, E., & D&CVD EASD Study Group. (2021). Heart failure in type 2 diabetes: Current perspectives on screening, diagnosis and management. Cardiovascular Diabetology, 20(1), 218. https://doi.org/10.1186/s12933‐021‐01408‐1
Chan, A. W., Tetzlaff, J. M., Gøtzsche, P. C., Altman, D. G., Mann, H., Berlin, J. A., Dickersin, K., Hróbjartsson, A., Schulz, K. F., Parulekar, W. R., Krleza‐Jeric, K., Laupacis, A., & Moher, D. (2013). SPIRIT 2013 explanation and elaboration: Guidance for protocols of clinical trials. BMJ (Clinical Research ed.), 346, e7586. https://doi.org/10.1136/bmj.e7586
Chang, R., Gulley, J. L., & Fong, L. (2023). Vaccinating against cancer: Getting to prime time. Journal for Immunotherapy of Cancer, 11(6), e006628. https://doi.org/10.1136/jitc‐2022‐006628
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet (London, England), 395(10223), 507–513. https://doi.org/10.1016/S0140‐6736(20)30211‐7
Chernoff, G. (2023). Combining topical dermal infused exosomes with injected calcium hydroxylapatite for enhanced tissue biostimulation. Journal of Cosmetic Dermatology, 22(1), 15–27. https://doi.org/10.1111/jocd.15695
Chu, M., Wang, H., Bian, L., Huang, J., Wu, D., Zhang, R., Fei, F., Chen, Y., & Xia, J. (2022). Nebulization therapy with umbilical cord mesenchymal stem cell‐derived exosomes for COVID‐19 pneumonia. Stem cell reviews and reports, 18(6), 2152–2163. https://doi.org/10.1007/s12015‐022‐10398‐w
Ciullo, A., Li, C., Li, L., Ungerleider, K. C., Peck, K., Marbán, E., & Ibrahim, A. G. E. (2022). Biodistribution of unmodified cardiosphere‐derived cell extracellular vesicles using single RNA tracing. Journal of Extracellular Vesicles, 11(1), e12178. https://doi.org/10.1002/jev2.12178
Couch, Y., Buzàs, E. I., Di Vizio, D., Gho, Y. S., Harrison, P., Hill, A. F., Lötvall, J., Raposo, G., Stahl, P. D., Théry, C., Witwer, K. W., & Carter, D. R. F. (2021). A brief history of nearly EV‐erything ‐ The rise and rise of extracellular vesicles. Journal of Extracellular Vesicles, 10(14), e12144. https://doi.org/10.1002/jev2.12144
Cui, G. H., Wu, J., Mou, F. F., Xie, W. H., Wang, F. B., Wang, Q. L., Fang, J., Xu, Y. W., Dong, Y. R., Liu, J. R., & Guo, H. D. (2018). Exosomes derived from hypoxia‐preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 32(2), 654–668. https://doi.org/10.1096/fj.201700600R
Dai, S., Wei, D., Wu, Z., Zhou, X., Wei, X., Huang, H., & Li, G. (2008). Phase I clinical trial of autologous ascites‐derived exosomes combined with GM‐CSF for colorectal cancer. Molecular Therapy : The Journal of the American Society of Gene Therapy, 16(4), 782–790. https://doi.org/10.1038/mt.2008.1
Del Rivero, T., Milberg, J., Bennett, C., Mitrani, M. I., & Bellio, M. A. (2022). Human amniotic fluid derived extracellular vesicles attenuate T cell immune response. Frontiers in Immunology, 13, 977809. https://doi.org/10.3389/fimmu.2022.977809
Dreschnack, P. A., & Belshaku, I. (2023). Treatment of idiopathic facial paralysis (Bell's Palsy) and secondary facial paralysis with extracellular vesicles: A pilot safety study. BMC Neurology, 23(1), 342. https://doi.org/10.1186/s12883‐023‐03400‐6
EclinicalMedicine (2021). Alzheimer's disease: Still in need of a cure! EClinicalMedicine. 2021;39:101146.
Escudier, B., Dorval, T., Chaput, N., André, F., Caby, M. P., Novault, S., Flament, C., Leboulaire, C., Borg, C., Amigorena, S., Boccaccio, C., Bonnerot, C., Dhellin, O., Movassagh, M., Piperno, S., Robert, C., Serra, V., Valente, N., Le Pecq, J. B., … Zitvogel, L. (2005). Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived‐exosomes: Results of thefirst phase I clinical trial. Journal of Translational Medicine, 3(1), 10. https://doi.org/10.1186/1479‐5876‐3‐10
Esfahani, K., Roudaia, L., Buhlaiga, N., Del Rincon, S. V., Papneja, N., & Miller, W. H., Jr (2020). A review of cancer immunotherapy: From the past, to the present, to the future. Current Oncology (Toronto, Ont.), 27(Suppl2), S87–S97. https://doi.org/10.3747/co.27.5223
Estévez‐Souto, V., Da Silva‐Álvarez, S., & Collado, M. (2023). The role of extracellular vesicles in cellular senescence. The FEBS Journal, 290(5), 1203–1211. https://doi.org/10.1111/febs.16585
Ezra, E., Gregor, Z. J., & Morfields Macular Hole Study Ggroup Report No. 1. (2004). Surgery for idiopathic full‐thickness macular hole: Two‐year results of a randomized clinical trial comparing natural history, vitrectomy, and vitrectomy plus autologous serum: Morfields Macular Hole Study Group RAeport no. 1. Archives of Ophthalmology (Chicago, Ill. : 1960), 122(2), 224–236. https://doi.org/10.1001/archopht.122.2.224
Fujiwara, H., Maeda, Y., Kobayashi, K., Nishimori, H., Matsuoka, K., Fujii, N., Kondo, E., Tanaka, T., Chen, L., Azuma, M., Yagita, H., & Tanimoto, M. (2014). Programmed death‐1 pathway in host tissues ameliorates Th17/Th1‐mediated experimental chronic graft‐versus‐host disease. Journal of Immunology (Baltimore, Md. : 1950), 193(5), 2565–2573. https://doi.org/10.4049/jimmunol.1400954
Gül, F., Gonen, Z. B., Jones, O. Y., Taşlı, N. P., Zararsız, G., Ünal, E., Özdarendeli, A., Şahin, F., Eken, A., Yılmaz, S., Karakukçu, M., Kırbaş, O. K., Gökdemir, N. S., Bozkurt, B. T., Özkul, Y., Oktay, B. D., Uygut, M. A., Cinel, I., & Çetin, M. (2022). A pilot study for treatment of severe COVID‐19 pneumonia by aerosolized formulation of convalescent human immune plasma exosomes (ChipEXO™). Frontiers in Immunology, 13, 963309. https://doi.org/10.3389/fimmu.2022.963309
Gelibter, S., Marostica, G., Mandelli, A., Siciliani, S., Podini, P., Finardi, A., & Furlan, R. (2022). The impact of storage on extracellular vesicles: A systematic study. Journal of Extracellular Vesicles, 11(2), e12162. https://doi.org/10.1002/jev2.12162
Gibello, L., D'Antico, S., Salafia, M., Senetta, R., Pomatto, M. A. C., Orlando, G., Sarcinella, A., Lopatina, T., Quaglino, P., Lorenzi, M., Verzini, F., Camussi, G., & Brizzi, M. F. (2023). First pilot case‐control interventional study using autologous extracellular vesicles to treat chronic venous ulcers unresponsive to conventional treatments. Pharmacological Research, 190, 106718. https://doi.org/10.1016/j.phrs.2023.106718
Glyn‐Jones, S., Palmer, A. J., Agricola, R., Price, A. J., Vincent, T. L., Weinans, H., & Carr, A. J. (2015). Osteoarthritis. Lancet (London, England), 386(9991), 376–387. https://doi.org/10.1016/S0140‐6736(14)60802‐3
Gotoh, K., Yatabe, Y., Sugiura, T., Takagi, K., Ogawa, M., Takahashi, T., Takahashi, T., & Mitsudomi, T. (1998). Frequency of MAGE‐3 gene expression in HLA‐A2 positive patients with non‐small cell lung cancer. Lung Cancer (Amsterdam, Netherlands), 20(2), 117–125. https://doi.org/10.1016/s0169‐5002(98)00017‐8
Guan, W. J., Ni, Z. Y., Hu, Y., Liang, W. H., Ou, C. Q., He, J. X., Liu, L., Shan, H., Lei, C. L., Hui, D. S. C., Du, B., Li, L. J., Zeng, G., Yuen, K. Y., Chen, R. C., Tang, C. L., Wang, T., Chen, P. Y., Xiang, J., … China Medical Treatment Expert Group for Covid‐19. (2020). Clinical characteristics of coronavirus disease 2019 in China. The New England Journal of Medicine, 382(18), 1708–1720. https://doi.org/10.1056/NEJMoa2002032
Gupta, A., Maffulli, N., Rodriguez, H. C., Mistovich, R. J., Delfino, K., Cady, C., Fauser, A. M., Cundiff, E. D., Martinez, M. A., & Potty, A. G. (2021). Cell‐free stem cell‐derived extract formulation for treatment of knee osteoarthritis: Study protocol for a preliminary non‐randomized, open‐label, multi‐center feasibility and safety study. Journal of Orthopaedic Surgery and Research, 16(1), 514. https://doi.org/10.1186/s13018‐021‐02672‐3
Han, H. S., Koh, Y. G., Hong, J. K., Roh, Y. J., Seo, S. J., & Park, K. Y. (2023). Adipose‐derived stem cell exosomes for treatment of dupilumab‐related facial redness in patients with atopic dermatitis. The Journal of Dermatological Treatment, 34(1), 2220444. https://doi.org/10.1080/09546634.2023.2220444
Herreros, M. D., Garcia‐Olmo, D., Guadalajara, H., Georgiev‐Hristov, T., Brandariz, L., & Garcia‐Arranz, M. (2019). Stem cell therapy: A compassionate use program in perianal fistula. Stem Cells International, 2019, 6132340. https://doi.org/10.1155/2019/6132340
Herrmann, I. K., Wood, M. J. A., & Fuhrmann, G. (2021). Extracellular vesicles as a next‐generation drug delivery platform. Nature Nanotechnology, 16(7), 748–759. https://doi.org/10.1038/s41565‐021‐00931‐2
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England), 395(10223), 497–506. https://doi.org/10.1016/S0140‐6736(20)30183‐5
Jang, B., Chung, H., Jung, H., Song, H. K., Park, E., Choi, H. S., Jung, K., Choe, H., Yang, S., & Oh, E. S. (2021). Extracellular vesicles from Korean Codium fragile and Sargassum fusiforme negatively regulate melanin synthesis. Molecules and Cells, 44(10), 736–745. https://doi.org/10.14348/molcells.2021.2167
Johnson, J., Law, S. Q. K., Shojaee, M., Hall, A. S., Bhuiyan, S., Lim, M. B. L., Silva, A., Kong, K. J. W., Schoppet, M., Blyth, C., Ranasinghe, H. N., Sejic, N., Chuei, M. J., Tatford, O. C., Cifuentes‐Rius, A., James, P. F., Tester, A., Dixon, I., & Lichtfuss, G. (2023). First‐in‐human clinical trial of allogeneic, platelet‐derived extracellular vesicles as a potential therapeutic for delayed wound healing. Journal of Extracellular Vesicles, 12(7), e12332. https://doi.org/10.1002/jev2.12332
Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. W. (2021). Biodistribution of extracellular vesicles following administration into animals: A systematic review. Journal of Extracellular Vesicles, 10(8), e12085. https://doi.org/10.1002/jev2.12085
Kantoff, P. W., Higano, C. S., Shore, N. D., Berger, E. R., Small, E. J., Penson, D. F., Redfern, C. H., Ferrari, A. C., Dreicer, R., Sims, R. B., Xu, Y., Frohlich, M. W., Schellhammer, P. F., & IMPACT Study Investigators. (2010). Sipuleucel‐T immunotherapy for castration‐resistant prostate cancer. The New England Journal of Medicine, 363(5), 411–422. https://doi.org/10.1056/NEJMoa1001294
Kordelas, L., Rebmann, V., Ludwig, A. K., Radtke, S., Ruesing, J., Doeppner, T. R., Epple, M., Horn, P. A., Beelen, D. W., & Giebel, B. (2014). MSC‐derived exosomes: A novel tool to treat therapy‐refractory graft‐versus‐host disease. Leukemia, 28(4), 970–973. https://doi.org/10.1038/leu.2014.41
Kwon, H. H., Yang, S. H., Lee, J., Park, B. C., Park, K. Y., Jung, J. Y., Bae, Y., & Park, G. H. (2020). Combination treatment with human adipose tissue stem cell‐derived exosomes and fractional CO2 laser for acne scars: A 12‐week prospective, double‐blind, randomized, split‐face study. Acta Dermato‐Venereologica, 100(18), adv00310. https://doi.org/10.2340/00015555‐3666
Lázaro‐Ibáñez, E., Faruqu, F. N., Saleh, A. F., Silva, A. M., Tzu‐Wen Wang, J., Rak, J., Al‐Jamal, K. T., & Dekker, N. (2021). Selection of fluorescent, bioluminescent, and radioactive tracers to accurately reflect extracellular vesicle biodistribution in Vivo. ACS Nano, 15(2), 3212–3227. https://doi.org/10.1021/acsnano.0c09873
Lamparski, H. G., Metha‐Damani, A., Yao, J. Y., Patel, S., Hsu, D. H., Ruegg, C., & Le Pecq, J. B. (2002). Production and characterization of clinical grade exosomes derived from dendritic cells. Journal of Immunological Methods, 270(2), 211–226. https://doi.org/10.1016/s0022‐1759(02)00330‐7
Lee, I., Choi, Y., Shin, D. U., Kwon, M., Kim, S., Jung, H., Nam, G. H., & Kwon, M. (2023). Small extracellular vesicles as a new class of medicines. Pharmaceutics, 15(2), 325. https://doi.org/10.3390/pharmaceutics15020325
Li, M., Soder, R., Abhyankar, S., Abdelhakim, H., Braun, M. W., Trinidad, C. V., Pathak, H. B., Pessetto, Z., Deighan, C., Ganguly, S., Dawn, B., McGuirk, J., Dunavin, N., & Godwin, A. K. (2021). WJMSC‐derived small extracellular vesicle enhance T cell suppression through PD‐L1. Journal of Extracellular Vesicles, 10(4), e12067. https://doi.org/10.1002/jev2.12067
Li, G., Chen, T., Dahlman, J., Eniola‐Adefeso, L., Ghiran, I. C., Kurre, P., Lam, W. A., Lang, J. K., Marbán, E., Martín, P., Momma, S., Moos, M., Nelson, D. J., Raffai, R. L., Ren, X., Sluijter, J. P. G., Stott, S. L., Vunjak‐Novakovic, G., Walker, N. D., … Sundd, P. (2023). Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases. Journal of Extracellular Vesicles, 12(2), e12305. https://doi.org/10.1002/jev2.12305
Lightner, A. L., Sengupta, V., Qian, S., Ransom, J. T., Suzuki, S., Park, D. J., Melson, T. I., Williams, B. P., Walsh, J. J., & Awili, M. (2023). Bone marrow mesenchymal stem cell‐derived extracellular vesicle infusion for the treatment of respiratory failure from COVID‐19: A randomized, placebo‐controlled dosing clinical trial. Chest, 164(6), 1444–1453. https://doi.org/10.1016/j.chest.2023.06.024
Lim, S. K., Giebel, B., Weiss, D. J., Witwer, K. W., & Rohde, E. (2020). Re: “Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID‐19” by Sengupta et al. Stem Cells and Development, 29(14), 877–878. https://doi.org/10.1089/scd.2020.0089
Messa, G. E., Tiongco, R. P., & Lau, F. H. (2022). Treatment of a recurrent ischial ulcer with injected exosomes. Journal of Surgical Case Reports, 2022(6), rjac271. https://doi.org/10.1093/jscr/rjac271
Mitrani, M. I., Bellio, M. A., Sagel, A., Saylor, M., Kapp, W., VanOsdol, K., Haskell, G., Stewart, D., Abdullah, Z., Santos, I., Milberg, J., Arango, A., Mitrani, A., & Shapiro, G. C. (2021a). Case report: Administration of amniotic fluid‐derived nanoparticles in three severely ill COVID‐19 patients. Frontiers in Medicine, 8, 583842. https://doi.org/10.3389/fmed.2021.583842
Mitrani, M. I., Bellio, M. A., Meglin, A., Khan, A., Xu, X., Haskell, G., Arango, A., & Shapiro, G. C. (2021b). Treatment of a COVID‐19 long hauler with an amniotic fluid‐derived extracellular vesicle biologic. Respiratory Medicine Case Reports, 34, 101502. https://doi.org/10.1016/j.rmcr.2021.101502
Morse, M. A., Garst, J., Osada, T., Khan, S., Hobeika, A., Clay, T. M., Valente, N., Shreeniwas, R., Sutton, M. A., Delcayre, A., Hsu, D. H., Le Pecq, J. B., & Lyerly, H. K. (2005). A phase I study of dexosome immunotherapy in patients with advanced non‐small cell lung cancer. Journal of Translational Medicine, 3(1), 9. https://doi.org/10.1186/1479‐5876‐3‐9
Nassar, W., El‐Ansary, M., Sabry, D., Mostafa, M. A., Fayad, T., Kotb, E., Temraz, M., Saad, A. N., Essa, W., & Adel, H. (2016). Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases. Biomaterials Research, 20, 21. https://doi.org/10.1186/s40824‐016‐0068‐0
Nazari, H., Alborzi, F., Heirani‐Tabasi, A., Hadizadeh, A., Asbagh, R. A., Behboudi, B., Fazeli, M. S., Rahimi, M., Keramati, M. R., Keshvari, A., Kazemeini, A., Soleimani, M., & Ahmadi Tafti, S. M. (2022). Evaluating the safety and efficacy of mesenchymal stem cell‐derived exosomes for treatment of refractory perianal fistula in IBD patients: Clinical trial phase I. Gastroenterology Report, 10, goac075. https://doi.org/10.1093/gastro/goac075
Norooznezhad, A. H., Yarani, R., Payandeh, M., Hoseinkhani, Z., Mahmoudi, H., Kiani, S., & Mansouri, K. (2023). Treatment of persistent chemotherapy‐induced hair loss (Alopecia) with human mesenchymal stromal cells exosome enriched extracellular vesicles: A case report. Heliyon, 9(4), e15165. https://doi.org/10.1016/j.heliyon.2023.e15165
Paicius, R., White, Z. S., Smith, C., Lightner, A. L., Ransom, J. T., Lee, D. W., & Speare, S. (2023). Safety and efficacy of intravenous ExoFlo in the treatment of complex regional pain syndrome. Pain Physician, 26(7), E851–E857.
Pak, H., Hadizadeh, A., Heirani‐Tabasi, A., Soleimani, M., Asbagh, R. A., Fazeli, M. S., Kazemeini, A., Keshvari, A., Keramati, M. R., Salahshour, F., Nazari, H., Tafti, S. M. A., & Behboudi, B. (2023). Safety and efficacy of injection of human placenta mesenchymal stem cells derived exosomes for treatment of complex perianal fistula in non‐Crohn's cases: Clinical trial phase I. Journal of Gastroenterology and Hepatology, 38(4), 539–547. https://doi.org/10.1111/jgh.16110
Pareschi, R., Lepera, D., & Nucci, R. (2019). Canal wall down approach for tympano‐mastoid cholesteatoma: Long‐term results and prognostic factors. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico‐facciale, 39(2), 122–129. https://doi.org/10.14639/0392‐100X‐2237
Park, K. Y., Han, H. S., Park, J. W., Kwon, H. H., Park, G. H., & Seo, S. J. (2022). Exosomes derived from human adipose tissue‐derived mesenchymal stem cells for the treatment of dupilumab‐related facial redness in patients with atopic dermatitis: A report of two cases. Journal of Cosmetic Dermatology, 21(2), 844–849. https://doi.org/10.1111/jocd.14153
Park, G. H., Kwon, H. H., Seok, J., Yang, S. H., Lee, J., Park, B. C., Shin, E., & Park, K. Y. (2023). Efficacy of combined treatment with human adipose tissue stem cell‐derived exosome‐containing solution and microneedling for facial skin aging: A 12‐week prospective, randomized, split‐face study. Journal of Cosmetic Dermatology, 22(12), 3418–3426. https://doi.org/10.1111/jocd.15872
Picca, A., Guerra, F., Calvani, R., Coelho‐Júnior, H. J., Landi, F., Bernabei, R., Romano, R., Bucci, C., & Marzetti, E. (2020). Extracellular vesicles and damage‐associated molecular patterns: A Pandora's box in health and disease. Frontiers in Immunology, 11, 601740. https://doi.org/10.3389/fimmu.2020.601740
Proffer, S. L., Paradise, C. R., DeGrazia, E., Halaas, Y., Durairaj, K. K., Somenek, M., Sivly, A., Boon, A. J., Behfar, A., & Wyles, S. P. (2022). Efficacy and tolerability of topical platelet exosomes for skin rejuvenation: Six‐week results. Aesthetic Surgery Journal, 42(10), 1185–1193. https://doi.org/10.1093/asj/sjac149
Roefs, M. T., Sluijter, J. P. G., & Vader, P. (2020). Extracellular vesicle‐associated proteins in tissue repair. Trends in Cell Biology, 30(12), 990–1013. https://doi.org/10.1016/j.tcb.2020.09.009
Sasaki, G. H. (2022). Clinical use of extracellular vesicles in the management of male and female pattern hair loss: A preliminary retrospective institutional review board safety and efficacy study. Aesthetic Surgery Journal. Open Forum, 4, ojac045. https://doi.org/10.1093/asjof/ojac045
Schwartz, D. A., Tagarro, I., Carmen Díez, M., & Sandborn, W. J. (2019). Prevalence of fistulizing Crohn's Disease in the United States: Estimate from a systematic literature review attempt and population‐based database analysis. Inflammatory Bowel Diseases, 25(11), 1773–1779. https://doi.org/10.1093/ibd/izz056
Sengupta, V., Sengupta, S., Lazo, A., Woods, P., Nolan, A., & Bremer, N. (2020). Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID‐19. Stem Cells and Development, 29(12), 747–754. https://doi.org/10.1089/scd.2020.0080
Sengupta, V., Sengupta, S., Lazo, A., Hicok, K. C., Jr, & Moseley, T. (2020). Response to Lim et al. re: “Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID‐19”. Stem Cells and Development, 29(14), 879–881. https://doi.org/10.1089/scd.2020.0095
Shekari, F., Abyadeh, M., Meyfour, A., Mirzaei, M., Chitranshi, N., Gupta, V., Graham, S. L., & Salekdeh, G. H. (2023). Extracellular vesicles as reconfigurable therapeutics for eye diseases: Promises and hurdles. Progress in Neurobiology, 225, 102437. https://doi.org/10.1016/j.pneurobio.2023.102437
Shen, Z., Huang, W., Liu, J., Tian, J., Wang, S., & Rui, K. (2021). Effects of mesenchymal stem cell‐derived exosomes on autoimmune diseases. Frontiers in Immunology, 12, 749192. https://doi.org/10.3389/fimmu.2021.749192
Shi, M. M., Yang, Q. Y., Monsel, A., Yan, J. Y., Dai, C. X., Zhao, J. Y., Shi, G. C., Zhou, M., Zhu, X. M., Li, S. K., Li, P., Wang, J., Li, M., Lei, J. G., Xu, D., Zhu, Y. G., & Qu, J. M. (2021). Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles. Journal of Extracellular Vesicles, 10(10), e12134. https://doi.org/10.1002/jev2.12134
Théry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001). Proteomic analysis of dendritic cell‐derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. Journal of Immunology (Baltimore, Md. : 1950), 166(12), 7309–7318. https://doi.org/10.4049/jimmunol.166.12.7309
Thakur, A. (2023). Shedding lights on the extracellular vesicles as functional mediator and therapeutic decoy for COVID‐19. Life (Basel, Switzerland), 13(3), 840. https://doi.org/10.3390/life13030840
Tieu, A., Hu, K., Gnyra, C., Montroy, J., Fergusson, D. A., Allan, D. S., Stewart, D. J., Thébaud, B., & Lalu, M. M. (2021). Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta‐analysis. Journal of Extracellular Vesicles, 10(12), e12141. https://doi.org/10.1002/jev2.12141
Tieu, A., Lalu, M. M., Slobodian, M., Gnyra, C., Fergusson, D. A., Montroy, J., Burger, D., Stewart, D. J., & Allan, D. S. (2020). An analysis of mesenchymal stem cell‐derived extracellular vesicles for preclinical use. ACS Nano, 14(8), 9728–9743. https://doi.org/10.1021/acsnano.0c01363
van der Grein, S. G., Defourny, K. A. Y., Slot, E. F. J., & Nolte‐’t Hoen, E. N. M. (2018). Intricate relationships between naked viruses and extracellular vesicles in the crosstalk between pathogen and host. Seminars in Immunopathology, 40(5), 491–504. https://doi.org/10.1007/s00281‐018‐0678‐9
Viaud, S., Ploix, S., Lapierre, V., Théry, C., Commere, P. H., Tramalloni, D., Gorrichon, K., Virault‐Rocroy, P., Tursz, T., Lantz, O., Zitvogel, L., & Chaput, N. (2011). Updated technology to produce highly immunogenic dendritic cell‐derived exosomes of clinical grade: A critical role of interferon‐γ. Journal of Immunotherapy (Hagerstown, Md. : 1997), 34(1), 65–75. https://doi.org/10.1097/CJI.0b013e3181fe535b5
Vozel, D., Božič, D., Jeran, M., Jan, Z., Pajnič, M., Pađen, L., Steiner, N., Kralj‐Iglič, V., & Battelino, S. (2021). Autologous platelet‐ and extracellular vesicle‐rich plasma is an effective treatment modality for chronic postoperative temporal bone cavity inflammation: Randomized controlled clinical trial. Frontiers in Bioengineering and Biotechnology, 9, 677541. https://doi.org/10.3389/fbioe.2021.677541
Wang, S. S., Jia, J., & Wang, Z. (2018). Mesenchymal stem cell‐derived extracellular vesicles suppresses iNOS expression and ameliorates neural impairment in Alzheimer's disease mice. Journal of Alzheimer's Disease : JAD, 61(3), 1005–1013. https://doi.org/10.3233/JAD‐170848
Warnecke, A., Prenzler, N., Harre, J., Köhl, U., Gärtner, L., Lenarz, T., Laner‐Plamberger, S., Wietzorrek, G., Staecker, H., Lassacher, T., Hollerweger, J., Gimona, M., & Rohde, E. (2021). First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles. Journal of Extracellular Vesicles, 10(8), e12094. https://doi.org/10.1002/jev2.12094
Wiklander, O. P. B., Brennan, M. Á., Lötvall, J., Breakefield, X. O., & El Andaloussi, S. (2019). Advances in therapeutic applications of extracellular vesicles. Science Translational Medicine, 11(492), eaav8521. https://doi.org/10.1126/scitranslmed.aav8521
Xie, X., Song, Q., Dai, C., Cui, S., Tang, R., Li, S., Chang, J., Li, P., Wang, J., Li, J., Gao, C., Chen, H., Chen, S., Ren, R., Gao, X., & Wang, G. (2023). Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells‐derived exosomes in patients with mild to moderate Alzheimer's disease: A phase I/II clinical trial. General Psychiatry, 36(5), e101143. https://doi.org/10.1136/gpsych‐2023‐101143
Xu, F., Yan, S., Wu, M., Li, F., Sun, Q., Lai, W., Shen, X., Rahhali, N., Taieb, C., & Xu, J. (2013). Self‐declared sensitive skin in China: A community‐based study in three top metropolises. Journal of the European Academy of Dermatology and Venereology: JEADV, 27(3), 370–375. https://doi.org/10.1111/j.1468‐3083.2012.04648.x
Yang, L., Zhu, J., Zhang, C., Wang, J., Yue, F., Jia, X., & Liu, H. (2019). Stem cell‐derived extracellular vesicles for myocardial infarction: A meta‐analysis of controlled animal studies. Aging, 11(4), 1129–1150. https://doi.org/10.18632/aging.101814
Ye, C., Zhang, Y., Su, Z., Wu, S., Li, Y., Yi, J., Lai, W., Chen, J., & Zheng, Y. (2022). hMSC exosomes as a novel treatment for female sensitive skin: An in vivo study. Frontiers in Bioengineering and Biotechnology, 10, 1053679. https://doi.org/10.3389/fbioe.2022.1053679
Yu, B., Shao, H., Su, C., Jiang, Y., Chen, X., Bai, L., Zhang, Y., Li, Q., Zhang, X., & Li, X. (2016). Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP‐1. Scientific Reports, 6, 34562. https://doi.org/10.1038/srep34562
Zarrabi, M., Shahrbaf, M. A., Nouri, M., Shekari, F., Hosseini, S. E., Hashemian, S. R., Aliannejad, R., Jamaati, H., Khavandgar, N., Alemi, H., Madani, H., Nazari, A., Amini, A., Hassani, S. N., Abbasi, F., Jarooghi, N., Fallah, N., Taghiyar, L., Ganjibakhsh, M., … Baharvand, H. (2023). Allogenic mesenchymal stromal cells and their extracellular vesicles in COVID‐19 induced ARDS: A randomized controlled trial. Stem Cell Research & Therapy, 14(1), 169. https://doi.org/10.1186/s13287‐023‐03402‐8
Zhang, X., Liu, J., Yu, B., Ma, F., Ren, X., & Li, X. (2018). Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 256(11), 2041–2052. https://doi.org/10.1007/s00417‐018‐4097‐3
Zhou, T., He, C., Lai, P., Yang, Z., Liu, Y., Xu, H., Lin, X., Ni, B., Ju, R., Yi, W., Liang, L., Pei, D., Egwuagu, C. E., & Liu, X. (2022). miR‐204‐containing exosomes ameliorate GVHD‐associated dry eye disease. Science Advances, 8(2), eabj9617. https://doi.org/10.1126/sciadv.abj9617
Zhu, Y. G., Shi, M. M., Monsel, A., Dai, C. X., Dong, X., Shen, H., Li, S. K., Chang, J., Xu, C. L., Li, P., Wang, J., Shen, M. P., Ren, C. J., Chen, D. C., & Qu, J. M. (2022). Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID‐19: A pilot study. Stem cell Research & Therapy, 13(1), 220. https://doi.org/10.1186/s13287‐022‐02900‐5
Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998). Eradication of established murine tumors using a novel cell‐free vaccine: Dendritic cell‐derived exosomes. Nature Medicine, 4(5), 594–600. https://doi.org/10.1038/nm0598‐594