Can the cyanide metabolite, 2-aminothiazoline-4-carboxylic acid, be used for forensic verification of cyanide poisoning?
2-amino-2-thiazoline-4-carboxylic acid
Biomarkers of cyanide exposure
Cyanide poisoning
Forensic analysis
Thiocyanate
Journal
Forensic toxicology
ISSN: 1860-8965
Titre abrégé: Forensic Toxicol
Pays: Japan
ID NLM: 101315563
Informations de publication
Date de publication:
13 May 2024
13 May 2024
Historique:
received:
11
12
2023
accepted:
17
04
2024
medline:
13
5
2024
pubmed:
13
5
2024
entrez:
13
5
2024
Statut:
aheadofprint
Résumé
Forensic verification of cyanide (CN) poisoning by direct CN analysis in postmortem blood is challenging due to instability of CN in biological samples. CN metabolites, thiocyanate (SCN CN, SCN Following CN poisoning, the concentration of each CN biomarker increased well above the baseline. In postmortem swine, CN concentrations declined rapidly (t While there are still questions to be answered, ATCA was the most adept forensic marker of CN poisoning (i.e., ATCA produced the longest half-life, the largest increase above baseline levels, and most stable background concentrations).
Identifiants
pubmed: 38739353
doi: 10.1007/s11419-024-00690-4
pii: 10.1007/s11419-024-00690-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R44NS97066-01A1
Pays : United States
Informations de copyright
© 2024. The Author(s).
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