Correlation of Serum and Gingival Crevicular Fluid Levels of Caspase-3 and Milk Fat Globule-Epidermal Growth Factor 8 on Gingival Health.
Journal
Indian journal of dental research : official publication of Indian Society for Dental Research
ISSN: 1998-3603
Titre abrégé: Indian J Dent Res
Pays: India
ID NLM: 9202990
Informations de publication
Date de publication:
01 Oct 2023
01 Oct 2023
Historique:
received:
23
01
2023
accepted:
08
09
2023
medline:
13
5
2024
pubmed:
13
5
2024
entrez:
13
5
2024
Statut:
ppublish
Résumé
This study aimed to estimate and correlate the serum and gingival crevicular fluid (GCF) levels of caspase-3 and milk fat globule-epidermal growth factor 8 (MFG-E8) in healthy, gingivitis and generalised chronic periodontitis subjects. A total of 24 subjects were selected and divided into three groups. After recording the periodontal parameters (plaque index (PI), modified gingival index (MGI), probing depth (PD) and clinical attachment level (CAL)), the serum and GCF samples were collected and the levels of caspase-3 and MFG-E8 were estimated using enzyme-linked immunoassay (ELISA). The mean values of PI, MGI, PD and CALs were significantly higher in group III when compared to group II and group I. The mean value of serum and GCF caspase-3 increased with increasing disease severity, whereas the mean serum and GCF values of MFG-E8 decreased with increasing severity of disease. Spearman's correlation showed a strong positive correlation between the serum and GCF levels of caspase-3 and periodontal parameters, whereas serum and GCF levels of MFG-E8 showed a strong negative correlation with the periodontal parameters. The findings of this study are suggestive that the serum and GCF levels of caspase-3 and MFG-E8 could serve as a potential biomarker for the role of apoptosis in periodontal disease. However, further studies are required to explore the mechanism and understand the relationship between these apoptotic markers and periodontitis.
Identifiants
pubmed: 38739812
doi: 10.4103/ijdr.ijdr_62_23
pii: 01363779-202334040-00004
doi:
Substances chimiques
Milk Proteins
0
Caspase 3
EC 3.4.22.-
Antigens, Surface
0
MFGE8 protein, human
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
359-364Informations de copyright
Copyright © 2024 Copyright: © 2024 Indian Journal of Dental Research.
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