How selective antagonists and genetic modification have helped characterise the expression and functions of vascular P2Y receptors.

AR-C118925XX Atherosclerosis Cangrelor Hypertension MRS2179 MRS2578 NF340 P2Y receptor PPTN Vasoconstriction Vasodilation

Journal

Purinergic signalling
ISSN: 1573-9546
Titre abrégé: Purinergic Signal
Pays: Netherlands
ID NLM: 101250499

Informations de publication

Date de publication:
13 May 2024
Historique:
received: 11 09 2023
accepted: 03 05 2024
medline: 14 5 2024
pubmed: 14 5 2024
entrez: 13 5 2024
Statut: aheadofprint

Résumé

Vascular P2Y receptors mediate many effects, but the role of individual subtypes is often unclear. Here we discuss how subtype-selective antagonists and receptor knockout/knockdown have helped identify these roles in numerous species and vessels. P2Y

Identifiants

pubmed: 38740733
doi: 10.1007/s11302-024-10016-z
pii: 10.1007/s11302-024-10016-z
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Ritter JM, Flower RJ, Henderson G, Loke YK, MacEwan D, Robinson E, Fullerton J (2024) Rang & Dale's Pharmacology, 10

Auteurs

Markie O Dales (MO)

Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK.

Robert M Drummond (RM)

Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK.

Charles Kennedy (C)

Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK. c.kennedy@strath.ac.uk.

Classifications MeSH