Transcriptomic evidence of erythropoietic adaptation from the International Space Station and from an Earth-based space analog.
Journal
NPJ microgravity
ISSN: 2373-8065
Titre abrégé: NPJ Microgravity
Pays: United States
ID NLM: 101703605
Informations de publication
Date de publication:
13 May 2024
13 May 2024
Historique:
received:
13
02
2024
accepted:
25
04
2024
medline:
14
5
2024
pubmed:
14
5
2024
entrez:
13
5
2024
Statut:
epublish
Résumé
Space anemia affects astronauts and the underlying molecular alterations remain unknown. We evaluated the response of erythropoiesis-modulating genes to spaceflight through the analysis of leukocyte transcriptomes from astronauts during long-duration spaceflight and from an Earth model of microgravity. Differential expression analysis identified 50 genes encoding ribosomal proteins with reduced expression at the transition to bed rest and increased during the bed rest phase; a similar trend was observed in astronauts. Additional genes associated with anemia (15 genes), erythrocyte maturation (3 genes), and hemoglobin (6 genes) were down-regulated during bed rest and increased during reambulation. Transcript levels of the erythropoiesis transcription factor GATA1 and nine of most enriched erythrocyte proteins increased at reambulation after bed rest and at return to Earth from space. Dynamic changes of the leukocyte transcriptome composition while in microgravity and during reambulation supported an erythropoietic modulation accompanying the hemolysis of space anemia and of immobility-induced anemia.
Identifiants
pubmed: 38740795
doi: 10.1038/s41526-024-00400-9
pii: 10.1038/s41526-024-00400-9
doi:
Types de publication
Journal Article
Langues
eng
Pagination
55Subventions
Organisme : Gouvernement du Canada | Canadian Space Agency (Agence Spatiale Canadienne)
ID : 19AOTTB24
Organisme : Gouvernement du Canada | Canadian Space Agency (Agence Spatiale Canadienne)
ID : 15EXBEDST
Organisme : Gouvernement du Canada | Canadian Space Agency (Agence Spatiale Canadienne)
ID : 19AOTTB24
Organisme : Gouvernement du Canada | Canadian Space Agency (Agence Spatiale Canadienne)
ID : 15EXBEDST
Organisme : Gouvernement du Canada | Canadian Space Agency (Agence Spatiale Canadienne)
ID : 15EXBEDST
Informations de copyright
© 2024. The Author(s).
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