Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial.


Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
13 May 2024
Historique:
received: 01 03 2024
accepted: 12 04 2024
medline: 14 5 2024
pubmed: 14 5 2024
entrez: 13 5 2024
Statut: aheadofprint

Résumé

In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes. Here in this prespecified analysis, we examined effects of semaglutide on weight and anthropometric outcomes, safety and tolerability by baseline body mass index (BMI). In patients treated with semaglutide, weight loss continued over 65 weeks and was sustained for up to 4 years. At 208 weeks, semaglutide was associated with mean reduction in weight (-10.2%), waist circumference (-7.7 cm) and waist-to-height ratio (-6.9%) versus placebo (-1.5%, -1.3 cm and -1.0%, respectively; P < 0.0001 for all comparisons versus placebo). Clinically meaningful weight loss occurred in both sexes and all races, body sizes and regions. Semaglutide was associated with fewer serious adverse events. For each BMI category (<30, 30 to <35, 35 to <40 and ≥40 kg m

Identifiants

pubmed: 38740993
doi: 10.1038/s41591-024-02996-7
pii: 10.1038/s41591-024-02996-7
doi:

Banques de données

ClinicalTrials.gov
['NCT03574597']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Donna H Ryan (DH)

Pennington Biomedical Research Center, Baton Rouge, LA, USA. ryandh@pbrc.edu.

Ildiko Lingvay (I)

Department of Internal Medicine/Endocrinology and Peter O' Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.

John Deanfield (J)

Institute of Cardiovascular Science, University College London, London, UK.

Steven E Kahn (SE)

VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA.

Eric Barros (E)

Novo Nordisk A/S, Søborg, Denmark.

Bartolome Burguera (B)

Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA.

Helen M Colhoun (HM)

Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Cintia Cercato (C)

Obesity Unit, Department of Endocrinology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.

Dror Dicker (D)

Internal Medicine Department D, Hasharon Hospital-Rabin Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Deborah B Horn (DB)

Center for Obesity Medicine and Metabolic Performance, Department of Surgery, University of Texas McGovern Medical School, Houston, TX, USA.

G Kees Hovingh (GK)

Novo Nordisk A/S, Søborg, Denmark.

Ole Kleist Jeppesen (OK)

Novo Nordisk A/S, Søborg, Denmark.

Alexander Kokkinos (A)

First Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

A Michael Lincoff (AM)

Department of Cardiovascular Medicine, Cleveland Clinic, and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

Sebastian M Meyhöfer (SM)

Institute of Endocrinology & Diabetes, University of Lübeck, Lübeck, Germany.

Tugce Kalayci Oral (TK)

Novo Nordisk A/S, Søborg, Denmark.

Jorge Plutzky (J)

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

André P van Beek (AP)

University of Groningen, University Medical Center Groningen, Department of Endocrinology, Groningen, the Netherlands.

John P H Wilding (JPH)

Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool, UK.

Robert F Kushner (RF)

Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Classifications MeSH