Investigating a novel surrogate indicator of adipose accumulation in relation to erectile dysfunction.
Erectile dysfunction
METS-VF
NHANES
Obesity
Journal
Lipids in health and disease
ISSN: 1476-511X
Titre abrégé: Lipids Health Dis
Pays: England
ID NLM: 101147696
Informations de publication
Date de publication:
13 May 2024
13 May 2024
Historique:
received:
28
02
2024
accepted:
23
04
2024
medline:
14
5
2024
pubmed:
14
5
2024
entrez:
14
5
2024
Statut:
epublish
Résumé
Although previous studies have linked obesity and erectile dysfunction, the novel surrogate indicators of adipose accumulation are more essential and dependable factors to consider. Therefore, the primary objective of the current investigation was to examine and clarify the association between metabolic score for visceral fat (METS-VF) and erectile dysfunction. Firstly, multivariate logistic regression analysis, smoothed curve fitting, and threshold effect analysis were employed to investigate the association between METS-VF and erectile dysfunction. Mediation analysis was also performed to evaluate the mediating role of homocysteine and inflammation. After that, subgroup analysis was carried out to examine the stability of the correlation of METS-VF with erectile dysfunction in various population settings. Furthermore, the area under the receiver operating characteristic (ROC) curve and eXtreme Gradient Boosting (XGBoost) algorithm were utilized to assess the capability of identifying METS-VF in comparison to the other four obesity-related indicators in identifying erectile dysfunction. After adjusting for all confounding factors, METS-VF was strongly and favourablely correlated with erectile dysfunction. With each additional unit rise in METS-VF, the prevalence of erectile dysfunction increased by 141%. A J-shaped relationship between METS-VF and erectile dysfunction was discovered through smoothed curve fitting. Marital status, physical activity, and smoking status can potentially modify this association. This finding of the ROC curve suggests that METS-VF had a powerful identifying capacity for erectile dysfunction (AUC = 0.7351). Homocysteine and inflammation mediated 4.24% and 2.81%, respectively. The findings of the current investigation suggest that METS-VF can be considered a dependable identifying indicator of erectile dysfunction.
Identifiants
pubmed: 38741154
doi: 10.1186/s12944-024-02118-9
pii: 10.1186/s12944-024-02118-9
doi:
Substances chimiques
Biomarkers
0
Homocysteine
0LVT1QZ0BA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
139Informations de copyright
© 2024. The Author(s).
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