H2A.Z chaperones converge on E2F target genes for melanoma cell proliferation.

H2A.Z epigenetics histone chaperones histone variants melanoma

Journal

Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660

Informations de publication

Date de publication:
14 May 2024
Historique:
received: 27 11 2023
accepted: 29 04 2024
medline: 15 5 2024
pubmed: 15 5 2024
entrez: 14 5 2024
Statut: aheadofprint

Résumé

High levels of H2A.Z promote melanoma cell proliferation and correlate with poor prognosis. However, the role of the two distinct H2A.Z histone chaperone complexes SRCAP and P400-TIP60 in melanoma remains unclear. Here, we show that individual subunit depletion of

Identifiants

DOI: 10.1101/gad.351318.123 PMID: 38744503
pubmed: 38744503
pii: gad.351318.123
doi: 10.1101/gad.351318.123
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 Jostes et al.; Published by Cold Spring Harbor Laboratory Press.

Auteurs

Sina Jostes (S)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Chiara Vardabasso (C)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Joanna Dong (J)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Saul Carcamo (S)

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Bioinformatics for Next-Generation Sequencing Facility, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Rajendra Singh (R)

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Robert Phelps (R)

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Austin Meadows (A)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Elena Grossi (E)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Dan Hasson (D)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Bioinformatics for Next-Generation Sequencing Facility, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Emily Bernstein (E)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA; emily.bernstein@mssm.edu.
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Classifications MeSH