Efficacy of seventh generation bonding agents as desensitizers in patients with dentin hypersensitivity: a randomized clinical trial.
Humans
Dentin Sensitivity
/ drug therapy
Female
Double-Blind Method
Male
Adult
Dentin Desensitizing Agents
/ therapeutic use
Dentin-Bonding Agents
/ therapeutic use
Fluorides, Topical
/ therapeutic use
Fluorides
/ therapeutic use
Young Adult
Bisphenol A-Glycidyl Methacrylate
/ therapeutic use
Treatment Outcome
Resin Cements
/ therapeutic use
Pain Measurement
Bonding agents
Dentin hypersensitivity
Gingival recession
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
14 May 2024
14 May 2024
Historique:
received:
14
11
2023
accepted:
09
05
2024
medline:
15
5
2024
pubmed:
15
5
2024
entrez:
14
5
2024
Statut:
epublish
Résumé
Dentin hypersensitivity (DH) is one of the most challenging and persistent dental complaints characterized by transient, intense pain triggered by various stimuli. It affects a significant portion of the global population, predominantly those aged 20-40. This study aims to evaluate the desensitizing efficacy of seventh-generation dentin bonding agents (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) against a control group using Bifluorid 12 by Voco in mitigating DH within a month of the follow-up period. This was a single-center, parallel-group, double-blind, controlled randomized clinical trial conducted at Dow University of Health Sciences, Karachi, Pakistan. A total of 105 patients with DH were allocated into three groups for this study. The patients were divided into three groups (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) and the control group containing fluoride varnish (Bifluorid 12 by Voco). Discomfort Interval Scale scores and Schiff Cold Air Sensitivity Scale scores were recorded at baseline, immediately after the intervention, after 01 weeks, and after 01 month. All the materials demonstrated a statistically significant reduction in discomfort and sensitivity (DIS scores p-value 0.01) immediately after 01 week and over a period of 01 month after treatment compared with the baseline scores before application, with no single material proving superior over the one-month observation period. The study also provided insights into dental hygiene practices, with a significant majority using a toothbrush and sensitivity patterns, with cold stimuli being the most common cause of sensitivity. The study demonstrates that Single Bond Universal, Xeno V+, and Bifluorid 12 are equally effective in reducing dentin hypersensitivity, with no distinct superiority observed over a one-month period. The findings highlight the potential of fluoride varnishes as a less technique-sensitive and cost-effective option for treating DH, offering valuable insights for future research and clinical practice. NCT04225247 ( https://clinicaltrials.gov/study/NCT04225247 ), Date of Registration: 13/01/2020. (Retrospectively registered).
Sections du résumé
BACKGROUND
BACKGROUND
Dentin hypersensitivity (DH) is one of the most challenging and persistent dental complaints characterized by transient, intense pain triggered by various stimuli. It affects a significant portion of the global population, predominantly those aged 20-40. This study aims to evaluate the desensitizing efficacy of seventh-generation dentin bonding agents (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) against a control group using Bifluorid 12 by Voco in mitigating DH within a month of the follow-up period.
METHODS
METHODS
This was a single-center, parallel-group, double-blind, controlled randomized clinical trial conducted at Dow University of Health Sciences, Karachi, Pakistan. A total of 105 patients with DH were allocated into three groups for this study. The patients were divided into three groups (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) and the control group containing fluoride varnish (Bifluorid 12 by Voco). Discomfort Interval Scale scores and Schiff Cold Air Sensitivity Scale scores were recorded at baseline, immediately after the intervention, after 01 weeks, and after 01 month.
RESULTS
RESULTS
All the materials demonstrated a statistically significant reduction in discomfort and sensitivity (DIS scores p-value 0.01) immediately after 01 week and over a period of 01 month after treatment compared with the baseline scores before application, with no single material proving superior over the one-month observation period. The study also provided insights into dental hygiene practices, with a significant majority using a toothbrush and sensitivity patterns, with cold stimuli being the most common cause of sensitivity.
CONCLUSION
CONCLUSIONS
The study demonstrates that Single Bond Universal, Xeno V+, and Bifluorid 12 are equally effective in reducing dentin hypersensitivity, with no distinct superiority observed over a one-month period. The findings highlight the potential of fluoride varnishes as a less technique-sensitive and cost-effective option for treating DH, offering valuable insights for future research and clinical practice.
TRIAL REGISTRATION
BACKGROUND
NCT04225247 ( https://clinicaltrials.gov/study/NCT04225247 ), Date of Registration: 13/01/2020. (Retrospectively registered).
Identifiants
pubmed: 38745306
doi: 10.1186/s12903-024-04352-0
pii: 10.1186/s12903-024-04352-0
doi:
Banques de données
ClinicalTrials.gov
['NCT04225247']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
562Informations de copyright
© 2024. The Author(s).
Références
West NX, et al. Prevalence of dentine hypersensitivity and study of associated factors: a European population-based cross-sectional study. J Dent. 2013;41(10):841–51.
doi: 10.1016/j.jdent.2013.07.017
pubmed: 23911597
Kar PP, et al. Comparison of the effectiveness of three different desensitizing toothpastes in reducing dentin hypersensitivity: a 4-week clinical study. J Conservative Dentistry: JCD. 2019;22(2):181.
doi: 10.4103/JCD.JCD_304_18
pubmed: 31142990
pmcid: 6519181
Cox CF et al. Biological basis for clinical success: pulp protection and the tooth-restoration interface. Pract Periodontics Aesthet Dent, 1999. 11(7): p. 819 – 26; quiz 827.
Borges R, et al. How are bioactive ceramics shaping the future of dentin hypersensitivity management through glass ionomer cements and laser therapy? Mater Lett. 2024;354:135366.
doi: 10.1016/j.matlet.2023.135366
Arshad S, Zaidi SJA, Farooqui WA. Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial. BMC Oral Health. 2021;21:1–12.
doi: 10.1186/s12903-021-01864-x
Orchardson R, Gillam DG. Managing dentin hypersensitivity. J Am Dent Association. 2006;137(7):990–8.
doi: 10.14219/jada.archive.2006.0321
Clark GE, Troullos ES. Designing hypersensitivity clinical studies. Dental Clin N Am. 1990;34(3):531–44.
doi: 10.1016/S0011-8532(22)01133-8
Grover V, et al. ISP good clinical practice recommendations for the management of dentin hypersensitivity. J Indian Soc Periodontology. 2022;26(4):307.
doi: 10.4103/jisp.jisp_233_22
Erdemir U, et al. The efficacy of three desensitizing agents used to treat dentin hypersensitivity. J Am Dent Association. 2010;141(3):285–96.
doi: 10.14219/jada.archive.2010.0162
Gillam D, Koyi B. Dentin hypersensitivity in clinical practice. JP Medical Ltd.; 2020.
Hypersensitivity CABoD. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. J Can Dent Assoc. 2003;69(4):221–6.
de Oliveira RP, et al. Effect of desensitizing agents on dentin hypersensitivity after non-surgical periodontal therapy: a systematic review and meta-analysis. J Dent. 2020;103:103498.
doi: 10.1016/j.jdent.2020.103498
pubmed: 33069772
Tyas MJ, Burrow MF. Adhesive restorative materials: a review. Aust Dent J, 2004. 49(3): p. 112 – 21; quiz 154.
Heaton LJ, Barlow AP, Coldwell SE. Development of labeled magnitude scales for the assessment of pain of dentin hypersensitivity. J Orofac Pain. 2013;27(1):72.
doi: 10.11607/jop.954
pubmed: 23424722
pmcid: 3610536
Rocha MOC, et al. Sensitivity and specificity of assessment scales of dentin hypersensitivity–an accuracy study. Brazilian oral Res. 2020;34:e043.
doi: 10.1590/1807-3107bor-2020.vol34.0043
Polderman R, Frencken J. Comparison between effectiveness of a low-viscosity glass ionomer and a resin-based glutaraldehyde containing primer in treating dentine hypersensitivity—a 25.2-month evaluation. J Dent. 2007;35(2):144–9.
doi: 10.1016/j.jdent.2006.06.005
pubmed: 16973252
Schiff T, et al. Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. J Clin Dent. 1994;5:87–92.
pubmed: 8534380
Mohd-Dom TN, et al. Oral health literacy and behavior of health sciences university students. J Dentistry Indonesia. 2015;22(2):56–62.
doi: 10.14693/jdi.v22i2.404
Riad A, et al. Czech and Slovak dental students’ oral health-related knowledge, attitudes, and behaviours (KAB): multi-country cross-sectional study. Int J Environ Res Public Health. 2022;19(5):2717.
doi: 10.3390/ijerph19052717
pubmed: 35270410
pmcid: 8910048
Akber A et al. Frequency of dentine hypersensitivity: a cross-sectional study. Pakistan Oral Dent J, 2016. 36(3).
Graf H, Galasse R. Morbidity, prevalence and intraoral distribution of hypersensitive teeth. J Dent Res. 1977;56(2):162.
Arthanari A et al. Etiology and management of hypersensitivity of Teeth-A Review. J Pharm Res Int, 2021: p. 317–29.
Vijaya V, et al. Association of dentine hypersensitivity with different risk factors–A cross sectional study. J Int oral Health: JIOH. 2013;5(6):88.
pubmed: 24453451
pmcid: 3895724
Amarasena N, et al. Dentine hypersensitivity in a private practice patient population in Australia. J Rehabil. 2011;38(1):52–60.
doi: 10.1111/j.1365-2842.2010.02132.x
Bahşi E, et al. An analysis of the aetiology, prevalence and clinical features of dentine hypersensitivity in a general dental population. Volume 16. European Review for Medical & Pharmacological Sciences; 2012. 8.
Rees J, et al. The prevalence of dentine hypersensitivity in a hospital clinic population in Hong Kong. J Dent. 2003;31(7):453–61.
doi: 10.1016/S0300-5712(03)00092-7
pubmed: 12927456
Ye W, Feng XP, Li R. The prevalence of dentine hypersensitivity in Chinese adults. J Rehabil. 2012;39(3):182–7.
doi: 10.1111/j.1365-2842.2011.02248.x
Cunha-Cruz J, et al. The prevalence of dentin hypersensitivity in general dental practices in the northwest United States. J Am Dent Assoc. 2013;144(3):288–96.
doi: 10.14219/jada.archive.2013.0116
pubmed: 23449905
pmcid: 3819160
Chabanski M, et al. Clinical evaluation of cervical dentine sensitivity in a population of patients referred to a specialist periodontology department: a pilot study. J Rehabil. 1997;24(9):666–72.
doi: 10.1111/j.1365-2842.1997.tb01079.x
Rane P, et al. Epidemiological study to evaluate the prevalence of dentine hypersensitivity among patients. J Int oral Health: JIOH. 2013;5(5):15.
pubmed: 24324299
pmcid: 3845279
Al-Otaibi M. The miswak (chewing stick) and oral health. Studies on oral hygiene practices of urban Saudi arabians. Swed Dent J Suppl, 2004(167): p. 2–75.
Wainwright J, Sheiham A. An analysis of methods of toothbrushing recommended by dental associations, toothpaste and toothbrush companies and in dental texts. Br Dent J. 2014;217(3):E5–5.
doi: 10.1038/sj.bdj.2014.651
pubmed: 25104719
Folayan MO, et al. Association between early childhood caries and poverty in low and middle income countries. BMC Oral Health. 2020;20:1–8.
doi: 10.1186/s12903-019-0991-2
Addy M. Dentine hypersensitivity: new perspectives on an old problem. Int Dent J. 2002;52(S5P2):367–75.
doi: 10.1002/j.1875-595X.2002.tb00936.x
Dhaliwal JS, et al. Prevalence of dentine hypersensitivity: a cross-sectional study in rural Punjabi indians. J Indian Soc Periodontology. 2012;16(3):426.
doi: 10.4103/0972-124X.100924
Rees J, Addy M. A cross-sectional study of buccal cervical sensitivity in UK general dental practice and a summary review of prevalence studies. Int J Dental Hygiene. 2004;2(2):64–9.
doi: 10.1111/j.1601-5029.2004.00068.x
Ritter AV, et al. Treating cervical dentin hypersensitivity with fluoride varnish. J Am Dent Association. 2006;137(7):1013–20.
doi: 10.14219/jada.archive.2006.0324
Torres CRG, et al. The effect of three desensitizing agents on dentin hypersensitivity: a randomized, split-mouth clinical trial. Oper Dent. 2014;39(5):E186–94.
doi: 10.2341/13-057
pubmed: 24720265
Yu X, et al. Comparative in vivo study on the desensitizing efficacy of dentin desensitizers and one-bottle self-etching adhesives. Oper Dent. 2010;35(3):279–86.
doi: 10.2341/09-346-C
pubmed: 20533627
Anderson CJ, Kugel G, Gerlach R. A randomized, controlled comparison of two professional dentin desensitizing agents immediately post-treatment and 2 months post-treatment. Am J Dent. 2018;31(6):297–302.
pubmed: 30658375
Nardi G, et al. Effectiveness of two different desensitizing varnishes in reducing tooth sensitivity: a randomized double-blind clinical trial. Volume 9. Oral & Implantology; 2016. p. 185. 4.
van Loveren C, et al. Dentin hypersensitivity management. Clin Dentistry Reviewed. 2018;2:1–10.
Ferrari M, et al. Clinical evaluation of a one-bottle bonding system for desensitizing exposed roots. Am J Dent. 1999;12(5):243–9.
pubmed: 10649916
Pandurić V, et al. The efficiency of dentine adhesives in treating non-caries cervical lesions. J Rehabil. 2001;28(12):1168–74.
doi: 10.1046/j.1365-2842.2001.00779.x
Kakaboura A, et al. Clinical effectiveness of two agents on the treatment of tooth cervical hypersensitivity. Am J Dent. 2005;18(4):291–5.
pubmed: 16296439
Patil SA, Naik BD, Suma R. Evaluation of three different agents for in-office treatment of dentinal hypersensitivity: a controlled clinical study. Indian J Dent Res. 2015;26(1):38.
doi: 10.4103/0970-9290.156796
pubmed: 25961613
Hajizadeh H, et al. Comparing the effect of a desensitizing material and a self-etch adhesive on dentin sensitivity after periodontal surgery: a randomized clinical trial. Volume 42. Restorative Dentistry & Endodontics; 2017. p. 168. 3.
Marto CM, et al. Evaluation of the efficacy of dentin hypersensitivity treatments—A systematic review and follow-up analysis. J Rehabil. 2019;46(10):952–90.
doi: 10.1111/joor.12842