Perilipins: A family of five fat-droplet storing proteins that play a significant role in fat homeostasis.
MASLD/MASH
fatty liver
hepatocellular carcinoma
lipid droplets
lipid homeostasis
perilipins
steatosis
Journal
Journal of cellular biochemistry
ISSN: 1097-4644
Titre abrégé: J Cell Biochem
Pays: United States
ID NLM: 8205768
Informations de publication
Date de publication:
15 May 2024
15 May 2024
Historique:
revised:
18
04
2024
received:
27
02
2024
accepted:
30
04
2024
medline:
15
5
2024
pubmed:
15
5
2024
entrez:
15
5
2024
Statut:
aheadofprint
Résumé
Lipid droplets are organelles with unique spherical structures. They consist of a hydrophobic neutral lipid core that varies depending on the cell type and tissue. These droplets are surrounded by phospholipid monolayers, along with heterogeneous proteins responsible for neutral lipid synthesis and metabolism. Additionally, there are specialized lipid droplet-associated surface proteins. Recent evidence suggests that proteins from the perilipin family (PLIN) are associated with the surface of lipid droplets and are involved in their formation. These proteins have specific roles in hepatic lipid droplet metabolism, such as protecting the lipid droplets from lipase action and maintaining a balance between lipid storage and utilization in specific cells. Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by the accumulation of lipid droplets in more than 5% of the hepatocytes. This accumulation can progress into metabolic dysfunction-associated steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The accumulation of hepatic lipid droplets in the liver is associated with the progression of MASLD and other diseases such as sarcopenic obesity. Therefore, it is crucial to understand the role of perilipins in this accumulation, as these proteins are key targets for developing novel therapeutic strategies. This comprehensive review aims to summarize the structure and characteristics of PLIN proteins, as well as their pathogenic role in the development of hepatic steatosis and fatty liver diseases.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Interdisciplinary Center for Clinical Research within the faculty of Medicine at the RWTH Aachen University
ID : PTD 1-5
Organisme : Deutsche Krebshilfe
ID : 70115581
Organisme : Deutsche Forschungsgemeinschaft
ID : WE2554/13-1
Organisme : Deutsche Forschungsgemeinschaft
ID : WE2554/15-1
Organisme : Deutsche Forschungsgemeinschaft
ID : WE2554/17-1
Informations de copyright
© 2024 The Authors. Journal of Cellular Biochemistry published by Wiley Periodicals LLC.
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